The development and feasibility of a personal health-optimization system for people with bipolar disorder

Table 2 Comparison to clinical practice guidelines and patient decision aids

Feature	System	AGREE	IPDAS
Predefined treatment options	x	x	x
Predefined patient-important criteria	x	x^a	x^a
Expected performances for all options on all criteria	x	0^b	x
Patient’s relative preferences for the outcomes, integrated in the mathematical calculation of expected values	x	0	0^c
Data collection plans	x	0	0
Notifications and reminders on smartphone	x	0	0
Collection of former treatment results	x	0	0
Collection of current treatment results	x	0	0
Collection of life events, health data and decision quality	x	0	0
Measurement of treatment and monitoring fidelity	x	0	0
Automatic modification of core decision components based on patient characteristics	x	0	0
The priorities of the individual patient, and relevant data from the patient, clinician and research, integrated mathematically to provide a ranking of treatments	x	0	0
Direct modification of core decision components available	x	0	0
Ranking of treatments based on mathematical integration includes uncertainty or quality of the evidence assessments	x	0^d	0^d
Comparison of expected performance of options	x	0	x
Expected performance of all options provided	x	x	x
Visualization of individual patient results over time	x	0	0
Statistical summaries and analyzes for the individual	x	0	0
Treatment strategy for the individual patient available	x	0	0
Agreed, main treatments for the individual accessible	x	0	0
Agreed, additional treatments for the individual accessible	x	0	0
Agreed, healthy habits for the individual accessible	x	0	0
Support for help from collaborators integrated in system	x	0	0

Comparison of core features in the health optimization system to the requirements in the AGREE and IPDAS standards for clinical practice guidelines and patient decision aids, respectively
^a According to AGREE, the benefits and risks should be considered but they do not have to be patient-important. According to IPDAS, criteria have to be provided but it is not explicitly stated that they have to be patient-important
^b Evidence should be searched systematically in general
^c Patients should be asked to consider which positive and negative features matter most
^d Uncertainty is included in the criteria but mathemathical integration is not a requirement

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