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Fig. 3 | BMC Medical Informatics and Decision Making

Fig. 3

From: Multiscalar cellular automaton simulates in-vivo tumour-stroma patterns calibrated from in-vitro assay data

Fig. 3

Results of parameter estimation from in-vitro data on the cell line MCF7. a 2D in-vitro cell growth from Incucyte data, as % of cell confluence (left) and standard deviation (right). They were used to calculate α T and β T respectively. b Illustration of HIF1α histopathology segmentation by colour deconvolution. The segmented patterns in red were quantified and the calculated the fractal dimension to estimate μ s and k s. c Example of HIF1α (top) and H&E (bottom) used to quantify the transversal distribution of hypoxia and necrosis (right). d Western blot data (n=3) showing the correlation of expression of HIF1α with atmospheric oxygen

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