From: CMOST: an open-source framework for the microsimulation of colorectal cancer screening strategies
Model parameter | Properties | Functional form (where applicable) |
---|---|---|
Age-dependent adenoma initiation risk | Defined by a sigmoidal function. | \( \frac{a_0}{1 + \exp \left(-\left({a}_1 y-{a}_2\right)\right)} \) |
Age-dependent early adenoma progression risk | Defined by a Gaussian function. | b _{0} exp(−(b _{1} y − b _{2})^{2}) |
Age-dependent advanced adenoma progression risk | Defined by a Gaussian function. | c _{0} exp(−(c _{1} y − c _{2})^{2}) |
Individual adenoma risk | Cumulative density function describing the relationship between population proportions and individual risk for appearance of new adenomas. Defined by automatically calibrated anchor points. | |
Early and advanced adenoma specific progression risk | Cumulative density function describing the relationship between early or advanced adenoma proportions and adenoma specific progression risk. Defined by manually calibrated anchor points. | |
Correction factors male/female for i) adenoma initiation ii) early adenoma progression iii) advanced adenoma progression | Constant | |
Correction factor rectum/colon for i) early adenoma progression ii) advanced adenoma progression | Constant | |
Adenoma stage-specific progression risk | Constant. One value for each adenoma stage 1-6, enables fine tuning of the distribution of adenoma stages 1-6 | |
Adenoma stage-specific regression risk | Constant. One value for each adenoma stage (1-6 highest for 1, lowest for 6); not calibrated | |
Adenoma stage-specific cancer risk | Constant. One value for each adenoma stage (1 to 5), calibrated to match prevalence of cancer in adenomas | |
Location specific direct cancer risk | Constant. One value for each colon segment 1-13 (calibrated to match CRC incidence reduction in rectosigmoidoscopy CRC prevention study) |