Fig. 1
From: CMOST: an open-source framework for the microsimulation of colorectal cancer screening strategies
Structure of the microsimulation model used in CMOST. Most cancers in CMOST start as adenomas (stages I to VI) and progress to cancer. Adenomas may be diagnosed and removed by screening interventions. Few cancers appear directly without adenoma precursors. Preclinical cancer can be diagnosed at an early stage by screening. Cancer develops in four stages. It can be detected by screening or due to symptoms. After detection, treatment can cure cancer with a stage-dependent probability