Table 2 Sensitivity, specificity, PPV and NPV of the optimal Boolean combinations in the construction and in the validation sample

Age

years

1

0.997549

0.78

1

0.956522

0.994545

0.511628

0.999739

BMI

kg/m²

0.973684

0.999777

0.973684

0.999777

0.454545

0.998958

0.789474

0.99533

Urea

mg/dl

1

0.78333

0.004065

1

1

0.822693

0.005797

1

Cholesterol

mg/dl

0.913043

0.999778

0.954545

0.999556

0.588235

1

1

0.998188

Cholesterol SI

mmol/l

0.956522

0.463366

0.00902

0.999521

0.375

0.443609

0.002788

0.994189

Creatinine

mg/dl

0.947368

0.727595

0.014446

0.999695

0.777778

0.825311

0.010264

0.999373

Diabetes

-

1

0.005797

0.009331

1

0.757576

0.015625

0.00657

0.882353

Education

-

0.866667

0.499778

0.005727

0.999114

0.888889

0.508799

0.004197

0.999492

Ethnicity

-

0.916667

0.998671

0.647059

0.999778

0.625

0.998706

0.5

0.999223

Event date

-

0.771084

0.455221

0.025755

0.990695

0.580645

0.407407

0.02354

0.975301

Fasting glucose

mg/dl

0.954545

0.980022

0.189189

0.999774

0.5625

0.994555

0.3

0.998179

Fasting glucose SI

mmol/l

1

0.015289

0.00314

1

0.866667

0.020477

0.003428

0.975309

Fibrinogen

mg/dl

0.928571

0.515622

0.005912

0.99957

1

0.556648

0.004067

1

Hemoglobin

g/dl

0.923077

0.145104

0.0031

0.998476

0.875

0.124191

0.002064

0.997921

Hemoglobin SI

g/l

1

0.024326

0.001132

1

0

0.047065

0

0.968085

Hba1c

%

0.944444

0.999113

0.809524

0.999778

0.666667

1

1

0.998965

HDL cholesterol

mg/dl

0.35

0.999334

0.7

0.997122

0.1875

0.998704

0.375

0.996636

HDL cholesterol SI

mmol/l

0.863636

0.978246

0.162393

0.99932

0.705882

0.977178

0.12

0.998675

History of CVD

-

0.611111

0.98368

0.311321

0.99525

0.348485

0.967923

0.277108

0.976801

Hs-CRP

mg/l

0.875

0.99823

0.466667

0.999778

1

0.998702

0.807692

1

Hypertension

-

0.941176

0.971511

0.2

0.999542

0.965517

0.961238

0.158192

0.999729

Intima Media Thickness (IMT)

0.1 mm

0.73494

0

0.013541

0

0.99115

0

0.057866

0

Intima Media Thickness (IMT) SI

mm

0.354911

0.989703

0.791045

0.933195

0.070588

0.969044

0.138462

0.936682

Arterial diameter

mm

0.685393

0.989184

0.559633

0.993662

0.509259

0.998406

0.901639

0.986097

Income

-

1

0

0.000884

0

1

0

0.000516

0

LDL cholesterol

mg/dl

0

1

0

0.995582

0

1

0

0.996902

LDL cholesterol

mmol/l

0.73913

0.992451

0.333333

0.99866

0.5

0.996368

0.391304

0.997662

Leukocytes

1/μl

0

0.993803

0

0.998

0

0.997411

0

0.997152

Dyslipidemia

-

0.923077

0.999335

0.8

0.999778

0.416667

0.998446

0.454545

0.998187

Antidiabetic medication

-

0.761905

0.997074

0.831169

0.995506

0.571429

0.998688

0.878049

0.992954

Antihypertensive medication

-

0.989362

0.591699

0.04887

0.999619

0.886364

0.607057

0.073724

0.993438

Lipid-lowering medication

-

0.987179

0.510227

0.034131

0.99956

0.982143

0.5093

0.028527

0.999486

Nicotine consumption

Pack years

0.8

1

1

0.998891

0.714286

0.999482

0.833333

0.998964

Carotid plaque

-

0.613636

0.999108

0.870968

0.996219

0.953757

1

1

0.997843

Diastolic blood pressure

mmHg

0.965116

0.985364

0.560811

0.999315

0.764706

0.983255

0.378641

0.996817

Systolic blood pressure

mmHg

0.674419

0.999775

0.983051

0.993733

0.510638

0.996602

0.648649

0.994004

Socioeconomic status

-

1

0.076514

0.004304

1

0.888889

0.072205

0.002227

0.996429

Sex

-

0.875

0.999334

0.875

0.999334

0.6875

0.998444

0.647059

0.998703

Smoking status

-

0.972603

0.20229

0.019592

0.997785

0.75

0.26145

0.013632

0.987154

Triglycerides

mg/dl

0.969697

0.136849

0.008182

0.998377

0

0.077201

0

1

Ultrasound date

-

0

0.999553

0

0.988729

0

1

0.988897

1

Average

0.799584

0.707405

0.34172

0.947871

0.619019

0.710383

0.325339

0.941999