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Table 2 Sensitivity, specificity, PPV and NPV of the optimal Boolean combinations in the construction and in the validation sample

From: Automatic identification of variables in epidemiological datasets using logic regression

Variable Unit Construction sample Validation sample
Sensitivity Specificity PPV NPV Sensitivity Specificity PPV NPV
Age years 1 0.997549 0.78 1 0.956522 0.994545 0.511628 0.999739
BMI kg/m2 0.973684 0.999777 0.973684 0.999777 0.454545 0.998958 0.789474 0.99533
Urea mg/dl 1 0.78333 0.004065 1 1 0.822693 0.005797 1
Cholesterol mg/dl 0.913043 0.999778 0.954545 0.999556 0.588235 1 1 0.998188
Cholesterol SI mmol/l 0.956522 0.463366 0.00902 0.999521 0.375 0.443609 0.002788 0.994189
Creatinine mg/dl 0.947368 0.727595 0.014446 0.999695 0.777778 0.825311 0.010264 0.999373
Diabetes - 1 0.005797 0.009331 1 0.757576 0.015625 0.00657 0.882353
Education - 0.866667 0.499778 0.005727 0.999114 0.888889 0.508799 0.004197 0.999492
Ethnicity - 0.916667 0.998671 0.647059 0.999778 0.625 0.998706 0.5 0.999223
Event date - 0.771084 0.455221 0.025755 0.990695 0.580645 0.407407 0.02354 0.975301
Fasting glucose mg/dl 0.954545 0.980022 0.189189 0.999774 0.5625 0.994555 0.3 0.998179
Fasting glucose SI mmol/l 1 0.015289 0.00314 1 0.866667 0.020477 0.003428 0.975309
Fibrinogen mg/dl 0.928571 0.515622 0.005912 0.99957 1 0.556648 0.004067 1
Hemoglobin g/dl 0.923077 0.145104 0.0031 0.998476 0.875 0.124191 0.002064 0.997921
Hemoglobin SI g/l 1 0.024326 0.001132 1 0 0.047065 0 0.968085
Hba1c % 0.944444 0.999113 0.809524 0.999778 0.666667 1 1 0.998965
HDL cholesterol mg/dl 0.35 0.999334 0.7 0.997122 0.1875 0.998704 0.375 0.996636
HDL cholesterol SI mmol/l 0.863636 0.978246 0.162393 0.99932 0.705882 0.977178 0.12 0.998675
History of CVD - 0.611111 0.98368 0.311321 0.99525 0.348485 0.967923 0.277108 0.976801
Hs-CRP mg/l 0.875 0.99823 0.466667 0.999778 1 0.998702 0.807692 1
Hypertension - 0.941176 0.971511 0.2 0.999542 0.965517 0.961238 0.158192 0.999729
Intima Media Thickness (IMT) 0.1 mm 0.73494 0 0.013541 0 0.99115 0 0.057866 0
Intima Media Thickness (IMT) SI mm 0.354911 0.989703 0.791045 0.933195 0.070588 0.969044 0.138462 0.936682
Arterial diameter mm 0.685393 0.989184 0.559633 0.993662 0.509259 0.998406 0.901639 0.986097
Income - 1 0 0.000884 0 1 0 0.000516 0
LDL cholesterol mg/dl 0 1 0 0.995582 0 1 0 0.996902
LDL cholesterol mmol/l 0.73913 0.992451 0.333333 0.99866 0.5 0.996368 0.391304 0.997662
Leukocytes 1/μl 0 0.993803 0 0.998 0 0.997411 0 0.997152
Dyslipidemia - 0.923077 0.999335 0.8 0.999778 0.416667 0.998446 0.454545 0.998187
Antidiabetic medication - 0.761905 0.997074 0.831169 0.995506 0.571429 0.998688 0.878049 0.992954
Antihypertensive medication - 0.989362 0.591699 0.04887 0.999619 0.886364 0.607057 0.073724 0.993438
Lipid-lowering medication - 0.987179 0.510227 0.034131 0.99956 0.982143 0.5093 0.028527 0.999486
Nicotine consumption Pack years 0.8 1 1 0.998891 0.714286 0.999482 0.833333 0.998964
Carotid plaque - 0.613636 0.999108 0.870968 0.996219 0.953757 1 1 0.997843
Diastolic blood pressure mmHg 0.965116 0.985364 0.560811 0.999315 0.764706 0.983255 0.378641 0.996817
Systolic blood pressure mmHg 0.674419 0.999775 0.983051 0.993733 0.510638 0.996602 0.648649 0.994004
Socioeconomic status - 1 0.076514 0.004304 1 0.888889 0.072205 0.002227 0.996429
Sex - 0.875 0.999334 0.875 0.999334 0.6875 0.998444 0.647059 0.998703
Smoking status - 0.972603 0.20229 0.019592 0.997785 0.75 0.26145 0.013632 0.987154
Triglycerides mg/dl 0.969697 0.136849 0.008182 0.998377 0 0.077201 0 1
Ultrasound date - 0 0.999553 0 0.988729 0 1 0.988897 1
Average   0.799584 0.707405 0.34172 0.947871 0.619019 0.710383 0.325339 0.941999