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Table 2 Top tier ranked up to 10th associated diseases

From: CLASH: Complementary Linkage with Anchoring and Scoring for Heterogeneous biomolecular and clinical data

Target Disease Associated via Reference Network Associated via Complemented Network
Celiac Disease Diabetes Mellitus
Metabolic Syndrome X
Glucose Intolerance
Hyperinsulinism
Hyperlipidemias
Calcinosis
Dyslipidemias
Hyperhomocysteinemia
Anemia, Iron-Deficiency
Homochromatosis
Diabetes Mellitus
Metabolic Syndrome X
Glucose Intolerance
Hyperinsulinism
Congentital Hyperinsulinism**
Malabsorption Syndromes*
Hypoglycemia**
Dyslipidemais
Hyperglycemia**
Hyperhomocysteinemia†
Lactose Intolerance Diabetes Mellitus
Metabolic Syndrome X
Glucose Intolerance
Celiac Disease
Dyslipidemias
Hyperinsulinism
Amyotrophic Lateral Sclerosis
Insulin Resistance
Hyperlipidemias
Glucose Metabolism Disorders
Mucolipidoses*
Celiac Disease*
Glycogen Storage Disease*
Metabolism, Inborn Errors*
Malabsorption Syndromes*
Diabetes Mellitus
Hypoglycemia**
Hyperinsulinism**
Glucose Intolerance**
Hypokalemia*
Hypophosphatasia Metabolic Syndrome X
Diabetes Mellitus
Glucose Intolerance
Metabolic Diseases
Dyslipidemias
Amyotrophic Lateral Sclerosis
Diabetes, Gestational
Hyperlipidemias
Hyperinsulinism
Calcinosis
Acidosis, Renal Tubular*
Zellweger Syndrome*
Celiac Disease*
Peroxisomal Disorders**
Refsum Disease*
Metabolism, Inborn Errors*
Adrenoleukodystrophy*
Homocystinuria**
Diabetes Mellitus
Phenylketonurias*
Refsum Disease Zellweger Syndrome
Peroxisomal Disorders
Chondrodysplasia Punctata, Rhizomelic
Adrenoleukodystrophy
Homocystinuria
Porphyrias
Protoporphyria, Erythropoietic
Hyperhomocysteinemia
Diabetic Ketoacidosis
Lipid Metabolism, Inborn Errors
Neuronal Ceroid-Lipofuscinoses*
Lipidoses*
Peroxisomal Disorders
Zellweger Syndrome
Diabetes Mellitus*
Leigh Disease*
Glycogen Storage Disease*
Adrenoleukodystrophy
Malabsorption Syndromes*
Glucose Intolerance**
Fanconi
Syndrome
Hypophosphatemia
Glycogen Storage Disease
Hypercalcemia
Glucose Intolerance
Metal Metabolism, Inborn Errors
Osteomalacia
Xanthomatosis, Cerebrotendinous
Diabetes Mellitus
Calcinosis
Metabolic Syndrome X
Celiac Disease*
Glycogen Storage Disease
Diabetes Mellitus
Carbohydrate Metabolism, Inborn Errors*
Leigh Disease*
Diabetes, Gestational*
Glucose Intolerance
Hyperinsulinism*
Hypoglycemia*
Congenital Hyperinsulinism**
Menkes Kinky Hair Syndrome N/A Congenital Disorders of Glycosylation*
Hyperglycinemia, Nonketotic*
Zellweger Syndrome*
Peroxisomal Disorders**
Hepatolenticular Degeneration*
Refsum Disease**
Acidosis, Lactic*
Albinism*
Mitochondrial Myopathies*
Adrenoleukodystrophy**
Pyruvate Carboxylase Deficiency
Disease
N/A Acidosis, Renal Tubular*
Carbohydrate Metabolism, Inborn Errors*
Hyperglycinemia, Nonketotic*
Maple Syrup Urine Disease*
Glycogen Storage Disease*
Amino Acid Metabolism, Inborn Errors*
Renal Aminoacidurias**
Metabolism, Inborn Errors*
Acidosis, Lactic*
Pyruvate Metabolism, Inborn Errors*
Rothmund-Thomson Syndrome N/A DNA Repair-Deficiency Disorders*
Celiac Disease*
Metal Metabolism, Inborn Errors**
Acidosis*
Xanthomatosis, Cerebrotendinous**
Hypercalcemia*
Skin Diseases, Metabolic*
Amyloidosis, Familial*
Achlorhydria**
Osteomalacia**
Sphingolipidoses N/A Neuronal Ceroid-Lipofuscinoses*
Lipidoses*
Carbohydrate Metabolism, Inborn Errors*
Diabetes Mellitus*
Peroxisomal Disorders*
Zellweger Syndrome**
Glycogen Storage Disease*
Adrenoleukodystrophy*
Refsum Disease*
Glucose Intolerance**
Alkaptonuria N/A Carbohydrate Metabolism, Inborn Errors*
Glycogen Storage Disease*
Zellweger Syndrome*
Metabolism, Inborn Errors*
Peroxisomal Disorders**
Amino Acid Metabolism, Inborn Errors*
Refsum Disease*
Adrenoleukodystrophy**
Diabetes Mellitus*
Lipid Metabolism, Inborn Errors*
  1. Notations ‘’, ‘*’ and ‘**’ are identical to those in Fig. 5