Table 2 Commonly used ADR measures and thresholds
From: Privacy preserving data anonymization of spontaneous ADE reporting system dataset
Measure | Formula | Threshold |
|---|---|---|
PRR | \( \frac{a/\left(a+b\right)}{c/\left(c+d\right)} \) | PRR − 1.96 × SD > 1 |
PRR ≥ 2, a ≥ 3, χ 2 ≥ 4 | ||
ROR | \( \frac{a/c}{b/d} \) | ROR − 1.96 × SD > 1 |
IC | \( { \log}_2\frac{a\left(a+b+c+d\right)}{\left(a+b\right)\left(a+c\right)} \) | Expect(IC) − 1.96 × SD > 0 |