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Table 2 The gene list used for module 1

From: Prognostic factor analysis for breast cancer using gene expression profiles

  Gene Description METABRIC BreastMark[17]
HR p-value HR p-value
High-expressed genes CHEK1 a, b checkpoint kinase 1 2.16 8.1E-11 1.32 3.9E-06
FOXM1 b forkhead box M1 2.58 4.4E-16 1.58 5.5E-13
CCNA2 a, b cyclin A2 2.53 5.8E-15 1.47 3.0E-09
CDC20 a, b cell division cycle 20 2.50 9.6E-15 1.54 5.8E-13
TTK a, b TTK protein kinase 2.28 1.5E-12 1.50 1.2E-11
CENPA a, b centromere protein A 2.56 4.4E-16 1.54 6.6E-13
KIF2C a, b kinesin family member 2C 2.49 5.6E-15 1.64 2.2E-16
BUB1 a BUB1, mitotic checkpoint serine/threonine kinase 2.50 2.1E-14 1.61 2.2E-15
MCM6 minichromosome maintenance complex component 6 2.09 3.5E-10 1.56 8.8E-14
LMNB2 b lamin B2 2.17 3.2E-11 1.38 2.6E-07
CDC45 b cell division cycle 45 2.53 2.6E-14 1.50 4.3E-12
ANLN a anillin actin binding protein 2.27 6.1E-12 1.48 1.1E-07
MCM10 b minichromosome maintenance 10 replication initiation factor 2.30 1.5E-12 1.62 9.8E-14
CDCA8 a, b cell division cycle associated 8 2.28 1.0E-12 1.55 3.8E-13
MELK b maternal embryonic leucine zipper kinase 2.56 3.6E-15 1.60 0
CCNB2 a cyclin B2 2.79 0 1.72 0
CEP55 a, b centrosomal protein 55 kDa 2.55 9.1E-15 1.56 1.8E-13
DLGAP5 a, b discs, large (Drosophila) homolog-associated protein 5 2.16 3.8E-10 1.46 3.6E-10
HJURP b Holliday junction recognition protein 2.79 0 1.61 2.3E-15
CDCA5 a cell division cycle associated 5 2.76 0 1.29 1.3E-03
TRIP13 a, b thyroid hormone receptor interactor 13 2.18 5.0E-11 1.44 6.6E-09
GTSE1 a, b G2 and S-phase expressed 1 2.54 1.7E-14 1.35 5.5E-07
CDCA3 a, b cell division cycle associated 3 2.29 5.3E-12 1.48 8.3E-10
PRR11 proline rich 11 2.09 1.3E-10 1.18 2.6E-06
FAM83D a family with sequence similarity 83 member D 2.66 2.2E-16 1.45 2.6E-06
GTPBP4 b GTP binding protein 4 1.73 1.6E-06 1.36 4.2E-07
Low-expressed genes ESR1 b estrogen receptor 1 0.54 2.6E-08 0.84 2.1E-02
GATA3 b GATA binding protein 3 0.57 4.0E-07 0.92 1.6E-01
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.49 3.0E-10 0.65 1.4E-12
RABEP1 b rabaptin, RAB GTPase binding effector protein 1 0.57 5.4E-07 0.75 2.3E-06
CIRBP b cold inducible RNA binding protein 0.44 1.1E-12 0.70 3.9E-09
EVL b Enah/Vasp-like 0.55 1.1E-07 0.78 1.0E-04
WDR19 WD repeat domain 19 0.52 1.5E-08 0.77 4.5E-05
SCUBE2 b signal peptide, CUB domain, EGF-like 2 0.55 1.7E-07 0.75 1.1E-04
KIF13B b kinesin family member 13B 0.55 3.8E-07 0.64 2.1E-11
TBC1D9 b TBC1 domain family member 9 0.55 1.2E-07 0.82 9.5E-04
ANKRA2 b ankyrin repeat family A member 2 0.55 6.2E-08 0.93 2.3E-01
DYNLRB2 dynein, light chain, roadblock-type 2 0.49 1.3E-09 0.93 3.9E-01
NME5 b NME/NM23 family member 5 0.44 3.8E-12 0.77 4.6E-05
CAPN8 calpain 8 0.54 1.5E-07 0.67 2.5E-02
CASC1 b cancer susceptibility candidate 1 0.44 1.8E-12 0.79 1.0E-04
BBOF1 basal body orientation factor 1 0.46 2.1E-11 0.78 7.5E-05
RUNDC1 RUN domain containing 1 0.55 1.0E-07 0.75 3.0E-04
  1. High expressed genes: high-expressed gene group associated with poor survival, Low expressed genes: low-expressed gene group associated with poor survival, agenes associated with the cell cycle process. bDifferentially expressed genes between triple-negative and non-triple-negative breast cancer, HR: hazard ratio, p-value: log-rank test