From: Prognostic factor analysis for breast cancer using gene expression profiles
Gene | Description | METABRIC | BreastMark[17] | |||
---|---|---|---|---|---|---|
HR | p-value | HR | p-value | |||
High-expressed genes | CHEK1 a, b | checkpoint kinase 1 | 2.16 | 8.1E-11 | 1.32 | 3.9E-06 |
FOXM1 b | forkhead box M1 | 2.58 | 4.4E-16 | 1.58 | 5.5E-13 | |
CCNA2 a, b | cyclin A2 | 2.53 | 5.8E-15 | 1.47 | 3.0E-09 | |
CDC20 a, b | cell division cycle 20 | 2.50 | 9.6E-15 | 1.54 | 5.8E-13 | |
TTK a, b | TTK protein kinase | 2.28 | 1.5E-12 | 1.50 | 1.2E-11 | |
CENPA a, b | centromere protein A | 2.56 | 4.4E-16 | 1.54 | 6.6E-13 | |
KIF2C a, b | kinesin family member 2C | 2.49 | 5.6E-15 | 1.64 | 2.2E-16 | |
BUB1 a | BUB1, mitotic checkpoint serine/threonine kinase | 2.50 | 2.1E-14 | 1.61 | 2.2E-15 | |
MCM6 | minichromosome maintenance complex component 6 | 2.09 | 3.5E-10 | 1.56 | 8.8E-14 | |
LMNB2 b | lamin B2 | 2.17 | 3.2E-11 | 1.38 | 2.6E-07 | |
CDC45 b | cell division cycle 45 | 2.53 | 2.6E-14 | 1.50 | 4.3E-12 | |
ANLN a | anillin actin binding protein | 2.27 | 6.1E-12 | 1.48 | 1.1E-07 | |
MCM10 b | minichromosome maintenance 10 replication initiation factor | 2.30 | 1.5E-12 | 1.62 | 9.8E-14 | |
CDCA8 a, b | cell division cycle associated 8 | 2.28 | 1.0E-12 | 1.55 | 3.8E-13 | |
MELK b | maternal embryonic leucine zipper kinase | 2.56 | 3.6E-15 | 1.60 | 0 | |
CCNB2 a | cyclin B2 | 2.79 | 0 | 1.72 | 0 | |
CEP55 a, b | centrosomal protein 55 kDa | 2.55 | 9.1E-15 | 1.56 | 1.8E-13 | |
DLGAP5 a, b | discs, large (Drosophila) homolog-associated protein 5 | 2.16 | 3.8E-10 | 1.46 | 3.6E-10 | |
HJURP b | Holliday junction recognition protein | 2.79 | 0 | 1.61 | 2.3E-15 | |
CDCA5 a | cell division cycle associated 5 | 2.76 | 0 | 1.29 | 1.3E-03 | |
TRIP13 a, b | thyroid hormone receptor interactor 13 | 2.18 | 5.0E-11 | 1.44 | 6.6E-09 | |
GTSE1 a, b | G2 and S-phase expressed 1 | 2.54 | 1.7E-14 | 1.35 | 5.5E-07 | |
CDCA3 a, b | cell division cycle associated 3 | 2.29 | 5.3E-12 | 1.48 | 8.3E-10 | |
PRR11 | proline rich 11 | 2.09 | 1.3E-10 | 1.18 | 2.6E-06 | |
FAM83D a | family with sequence similarity 83 member D | 2.66 | 2.2E-16 | 1.45 | 2.6E-06 | |
GTPBP4 b | GTP binding protein 4 | 1.73 | 1.6E-06 | 1.36 | 4.2E-07 | |
Low-expressed genes | ESR1 b | estrogen receptor 1 | 0.54 | 2.6E-08 | 0.84 | 2.1E-02 |
GATA3 b | GATA binding protein 3 | 0.57 | 4.0E-07 | 0.92 | 1.6E-01 | |
LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.49 | 3.0E-10 | 0.65 | 1.4E-12 | |
RABEP1 b | rabaptin, RAB GTPase binding effector protein 1 | 0.57 | 5.4E-07 | 0.75 | 2.3E-06 | |
CIRBP b | cold inducible RNA binding protein | 0.44 | 1.1E-12 | 0.70 | 3.9E-09 | |
EVL b | Enah/Vasp-like | 0.55 | 1.1E-07 | 0.78 | 1.0E-04 | |
WDR19 | WD repeat domain 19 | 0.52 | 1.5E-08 | 0.77 | 4.5E-05 | |
SCUBE2 b | signal peptide, CUB domain, EGF-like 2 | 0.55 | 1.7E-07 | 0.75 | 1.1E-04 | |
KIF13B b | kinesin family member 13B | 0.55 | 3.8E-07 | 0.64 | 2.1E-11 | |
TBC1D9 b | TBC1 domain family member 9 | 0.55 | 1.2E-07 | 0.82 | 9.5E-04 | |
ANKRA2 b | ankyrin repeat family A member 2 | 0.55 | 6.2E-08 | 0.93 | 2.3E-01 | |
DYNLRB2 | dynein, light chain, roadblock-type 2 | 0.49 | 1.3E-09 | 0.93 | 3.9E-01 | |
NME5 b | NME/NM23 family member 5 | 0.44 | 3.8E-12 | 0.77 | 4.6E-05 | |
CAPN8 | calpain 8 | 0.54 | 1.5E-07 | 0.67 | 2.5E-02 | |
CASC1 b | cancer susceptibility candidate 1 | 0.44 | 1.8E-12 | 0.79 | 1.0E-04 | |
BBOF1 | basal body orientation factor 1 | 0.46 | 2.1E-11 | 0.78 | 7.5E-05 | |
RUNDC1 | RUN domain containing 1 | 0.55 | 1.0E-07 | 0.75 | 3.0E-04 |