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Table 2 The gene list used for module 1

From: Prognostic factor analysis for breast cancer using gene expression profiles

 

Gene

Description

METABRIC

BreastMark[17]

HR

p-value

HR

p-value

High-expressed genes

CHEK1 a, b

checkpoint kinase 1

2.16

8.1E-11

1.32

3.9E-06

FOXM1 b

forkhead box M1

2.58

4.4E-16

1.58

5.5E-13

CCNA2 a, b

cyclin A2

2.53

5.8E-15

1.47

3.0E-09

CDC20 a, b

cell division cycle 20

2.50

9.6E-15

1.54

5.8E-13

TTK a, b

TTK protein kinase

2.28

1.5E-12

1.50

1.2E-11

CENPA a, b

centromere protein A

2.56

4.4E-16

1.54

6.6E-13

KIF2C a, b

kinesin family member 2C

2.49

5.6E-15

1.64

2.2E-16

BUB1 a

BUB1, mitotic checkpoint serine/threonine kinase

2.50

2.1E-14

1.61

2.2E-15

MCM6

minichromosome maintenance complex component 6

2.09

3.5E-10

1.56

8.8E-14

LMNB2 b

lamin B2

2.17

3.2E-11

1.38

2.6E-07

CDC45 b

cell division cycle 45

2.53

2.6E-14

1.50

4.3E-12

ANLN a

anillin actin binding protein

2.27

6.1E-12

1.48

1.1E-07

MCM10 b

minichromosome maintenance 10 replication initiation factor

2.30

1.5E-12

1.62

9.8E-14

CDCA8 a, b

cell division cycle associated 8

2.28

1.0E-12

1.55

3.8E-13

MELK b

maternal embryonic leucine zipper kinase

2.56

3.6E-15

1.60

0

CCNB2 a

cyclin B2

2.79

0

1.72

0

CEP55 a, b

centrosomal protein 55 kDa

2.55

9.1E-15

1.56

1.8E-13

DLGAP5 a, b

discs, large (Drosophila) homolog-associated protein 5

2.16

3.8E-10

1.46

3.6E-10

HJURP b

Holliday junction recognition protein

2.79

0

1.61

2.3E-15

CDCA5 a

cell division cycle associated 5

2.76

0

1.29

1.3E-03

TRIP13 a, b

thyroid hormone receptor interactor 13

2.18

5.0E-11

1.44

6.6E-09

GTSE1 a, b

G2 and S-phase expressed 1

2.54

1.7E-14

1.35

5.5E-07

CDCA3 a, b

cell division cycle associated 3

2.29

5.3E-12

1.48

8.3E-10

PRR11

proline rich 11

2.09

1.3E-10

1.18

2.6E-06

FAM83D a

family with sequence similarity 83 member D

2.66

2.2E-16

1.45

2.6E-06

GTPBP4 b

GTP binding protein 4

1.73

1.6E-06

1.36

4.2E-07

Low-expressed genes

ESR1 b

estrogen receptor 1

0.54

2.6E-08

0.84

2.1E-02

GATA3 b

GATA binding protein 3

0.57

4.0E-07

0.92

1.6E-01

LRIG1

leucine-rich repeats and immunoglobulin-like domains 1

0.49

3.0E-10

0.65

1.4E-12

RABEP1 b

rabaptin, RAB GTPase binding effector protein 1

0.57

5.4E-07

0.75

2.3E-06

CIRBP b

cold inducible RNA binding protein

0.44

1.1E-12

0.70

3.9E-09

EVL b

Enah/Vasp-like

0.55

1.1E-07

0.78

1.0E-04

WDR19

WD repeat domain 19

0.52

1.5E-08

0.77

4.5E-05

SCUBE2 b

signal peptide, CUB domain, EGF-like 2

0.55

1.7E-07

0.75

1.1E-04

KIF13B b

kinesin family member 13B

0.55

3.8E-07

0.64

2.1E-11

TBC1D9 b

TBC1 domain family member 9

0.55

1.2E-07

0.82

9.5E-04

ANKRA2 b

ankyrin repeat family A member 2

0.55

6.2E-08

0.93

2.3E-01

DYNLRB2

dynein, light chain, roadblock-type 2

0.49

1.3E-09

0.93

3.9E-01

NME5 b

NME/NM23 family member 5

0.44

3.8E-12

0.77

4.6E-05

CAPN8

calpain 8

0.54

1.5E-07

0.67

2.5E-02

CASC1 b

cancer susceptibility candidate 1

0.44

1.8E-12

0.79

1.0E-04

BBOF1

basal body orientation factor 1

0.46

2.1E-11

0.78

7.5E-05

RUNDC1

RUN domain containing 1

0.55

1.0E-07

0.75

3.0E-04

  1. High expressed genes: high-expressed gene group associated with poor survival, Low expressed genes: low-expressed gene group associated with poor survival, agenes associated with the cell cycle process. bDifferentially expressed genes between triple-negative and non-triple-negative breast cancer, HR: hazard ratio, p-value: log-rank test