Skip to main content

Advertisement

Table 2 Key findings in the clinical area of HIV/AIDS (Anti-retro Viral Therapy)

From: Positive influence of short message service and voice call interventions on adherence and health outcomes in case of chronic disease care: a systematic review

Lead Author/Year Country Study design Sample size Duration Age group Intervention Delivery frequency Measures of outcome Results Control (C) versus Intervention (I)
Cristian Pop-Eleches/2011 [32] Kenya RCT 428 12 months 18+ SMS- Short and long Short- daily, Long- weekly Adherence to ART Adherence of at least 90 % during 48 weeks of study in
I: 53 %
C: 40 %
Richard T Lester /2010 [25] Kenya RCT 538 12 months 18+ SMS Weekly Drug adherence, suppression of plasma viral load Adherence to ART
I: 61.5 %; C: 49.81 %. Suppressed plasma viral loads I: 60.4; C: 48.3 %.
Rashmi Rodrigues/2012 [33] India Quasi-experimental cohort 150 6 months 18+ Interactive voice call and picture message Weekly Adherence, Pill count Adherence at baseline, month 1, month 3, month 6, month 9 and month 12 were 85 %, 94 %, 93 %, 91 %, 95 %, and 94 % respectively.
Setor Kunutsor/2010 [24] Uganda Cross-sectional and descriptive 176 7 months 18+ Voice call and SMS 4 weekly Attendance. Drug refill Mean adherence before and after intervention was 96.3 % and 98.4 % respectively ((95 % confidence interval).
Dongsheng Huang/2013 [17] China RCT 172 3 months 18+ Voice call 2 weekly Adherence to ART and quality of life (QOL) CD4 count:
Baseline: Treatment naïve group
I: 191/mm3; C: 216/ mm3
Treatment experienced
I: 286/mm3; C: 348/ mm3.
End line: Treatment naïve group
I: 308/mm3; C: 298/ mm3.
Treatment experienced group-
I: 324/mm3; C: 356/ mm3.
Adherence rate: I: above 98 %, C: fluctuated slightly
Thiago Martini da Costa/2012 [8] Brazil RCT 21 4 months 18+ SMS Every alternative working day + Sat. + Sun. day Self-reported adherence, pill count Self-reported adherence
I: remained 100 % in I group, C: 100 to 92.31 %
Pill count
I: 75.00 to 62.50 %.
C: 69.23 to 46.15 %.
Lawrence Mbuagbaw/2012 [26] Cameroon RCT 200 6 months 21+ SMS Weekly Visual Analogue Scale, number of doses missed (in the week preceding interview), drug refill No significant effect on adherence by VAS > 95 % (risk ratio1.06, 95 % CI 0.89, 1.29; p = 0.542; reported missed doses (RR 1.01, 95 % CI 0.87, 1.16; p.0.999) or number of pharmacy refills (mean difference 0.1, 95 % CI: 0.23, 0.43; p = 0.617.
CD4 count at end of 3 months:
C: 327/mm3 to 375/mm3
I: 347/mm3 to 406/mm3.