Table 1 Eligibility criteria classification categories based on content

Addictive behavior^a

NOT (Suspected abuse of alcohol or other drug)

Address^a

Residents of selected deprived neighborhoods in the city of Sheffield

Age^a

Aged greater than 40 years

Allergy^a

NOT (Subjects with known hypersensitivity to sulfonamides)

Cancer^a

NOT (Patients with lung cancer)

Capacity^a

Dependence in functional activities of daily living requiring assistance

Compliance with protocol^a

Able to comply with the intervention and all study procedures

Consent^a

Consent to participate in the trial

Device^a

NOT (metal implants)

Diagnostic or lab results^a

Patients must have a measured post-albuterol/salbutamol FEV1/FVC ratio of <0.70 at Screening

Disease stage^a

NOT (with stage 0 or IV prolapse)

Disease, symptom and sign^a

Newly diagnosed depression

Enrollment in other studies^a

NOT (Patients currently in, or have been in another clinical trial in the previous 3 months)

Gender^a

Males

Life expectancy^a

Life expectancy must be at least 5 years

Literacy or spoken language^a

Be able to communicate in English sufficiently to complete questionnaires

Medication^a

On maximum dose of oral anti-diabetic drugs

Organ or tissue status^a

NOT (Organic brain damage)

Patient preference^a

Wish to participate

Pregnancy conditions^a

Pregnancy 8–18 weeks

Receptor status^a

Hormone receptor status not specified

Special patient characteristics^a

Owner of mobile phone

Therapy or procedure^a

All patients undergoing an elective primary total knee arthroplasty for osteoarthritis

Practice Geographic location

NHS general practices within a 50 mile radius of Manchester and Nottingham in England

Practice/practitioner specialty

NOT (under the care of the specialist mental health team)

Practitioner preference

Locality specialist who will support the participation of the practice and the implementation of standard guidelines across the participating practices.

Caregiver attribute

CARERS: Fluent in English