Prediction of delayed graft function after kidney transplantation: comparison between logistic regression and machine learning methods

Table 4 Weights of the selected features

Feature	Odds ratio (LR)^a	Z-score (linear SVM)^a	Gini index (RF)^b
Donor
Age (per 1 year)	1.060	0.744	0.037	(#9)
BMI (per 1 kg/m²)	0.751	−1.700	0.023	(#20)
Terminal SCr (per 1 mg/dL)	6.512	1.126	0.024	(#17.5)
Hypotensive episodes: yes vs. no	1.784	0.165	0.001	(#48.5)
Diabetes mellitus: yes vs. no	0.013	−1.041	0.001	(#48.5)
History of hypertension: yes vs. no	3.585	0.940	0.011	(#28)
Donor after cardiac death: yes vs. no	25.789	1.534	0.080	(#1)
Preservation/Operation
Machine perfusion: yes vs. no	0.003	−1.078	0.000	(#60)
Perioperative graft reperfusion^c	0.740	−0.844	0.027	(#14.5)
Preservation solution
HTK + UW	0.00005	−0.510	0.000	(#60)
UW	0.080	−1.557	0.016	(#25)
HTK	0.050	−1.725	0.007	(#32.5)
Male donor-to-female recipient: yes vs. no	0.352	−0.750	0.019	(#23)
Recipient
BMI (per 1 kg/m²)	1.144	0.941	0.054	(#4)
Duration of dialysis (per 1 day)	1.0005	0.324	0.057	(#3)
PRA at time of Tx (per 1 %)	0.977	−0.557	0.008	(#30.5)
Peak PRA (per 1 %)	1.017	0.585	0.025	(#16)
Acute CNI toxicity: yes vs. no	22.044	0.964	0.007	(#32.5)
Reduced cardiac function: yes vs. no	5.570	0.897	0.033	(#13)
Impaired ECV: yes vs. no	0.003	−1.141	0.000	(#60)
Urinary tract obstruction: yes vs. no	6.638	0.942	0.004	(#38.5)
Iliac artery
normal	1.520	0.221	0.001	(#48.5)
atheromatosis	2.389	0.573	0.006	(#34.5)
stenosis	28.465	0.948	0.037	(#9)

^aFitted on the reduced data set
^bFitted on the full data set. Tied rank amongst all 68 features is given in parentheses
^cPerioperative graft reperfusion is an ordinal feature (poor – patchy – moderate – good)
Abbreviations: BMI body mass index, CNI calcineurin inhibitor toxicity, ECV effective circulating volume, HTK histidine-tryptophan-ketoglutarate, LR logistic regression, PRA panel reactive antibody, RF random forest, SCr serum creatinine, SVM support vector machine, Tx transplantation, UW University of Wisconsin

ISSN: 1472-6947