Figure 5

Example of thea posterioridose estimation function. This shows an example of an a posteriori dose estimation for a 1.53 year old child, with bodyweight 20 kg, genotypes CYP2C9 *1/*1 and VKORC1 A/A, and target INR 2.0-3.0 and a baseline INR of 1 using the individual model parameters estimated in Figure 4. The estimated a posteriori dose is 1.08 mg/24 h, or 7.56 mg/week. The graph shows the predicted INR curve after administration of the estimated daily dose (1.08 mg).