Table 2 Patient profiles with missing or incomplete rules, and corresponding rules extracted from the database *

3

7

Diet and exercise (7;1) [100%]

Not applicable

4

51

Monotherapy (45;1) [100%]

sulfonylurea if dyslipidemia (7;0.89), else alpha glucosidase inhibitors if not already under biguanides (3;0.8); biguanides by default (11;0.92) [100%]

5

59

Bitherapy (56;1) [100%]

Biguanides and sulfonylurea [100%]

Metformine and gibenclamide [100%]

6

16

Insulin [+OAD]** if cholesterolemia ≤ 400 mg/dl (2;0.75), Tritherapy if not (12;0.93) [100%]

Biguanides, sulfonylurea and alpha glucosidase inhibitors if tritherapy [100%]

7

84

Insulin [+OAD]** (75;1) [100%]

Insulin only if already under insulin plus biguanides (62;0.65); Insulin with biguanides if postprandial glycemia >184 mg/dl and age<52 yrs (11;0.92); Insulin with sulfonylurea and alpha glucosidase inhibitors if already under sulfonylurea (11;0.63) [100%]

12

1

Oral bitherapy (mentioned in the guideline)

Biguanides and sulfonylurea [100%]

13

39

Oral bitherapy (mentioned in the guideline)

Biguanides and sulfonylurea if bitherapy [100%]

14

18

Insulin [+OAD]** (mentioned in the guideline)

15

18

Insulin [+OAD]** if morning glycemia >230 mg/dl (8;0.8), tritherapy if not (10;0.92) [100%]

Biguanides, sulfonylurea and alpha glucosidase inhibitors if tritherapy [100%]

16

123

Insulin [+OAD]** (114;1) [100%]

Insulin only if already under insulin plus sulfonylurea or insulin only (72;0.78); Insulin plus biguanides if already under insulin plus biguanides (24.5;0.83); insulin plus biguanides and sulfonylurea if not (17;0.36) [90.9%]

One injection of Insulin if accompanied by biguanides or sulfonylurea (10;0.83); Two injections of insulin [+OAD]** (104;0.79) [72.7%]