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Table 1 Diagnostic criteria and organ dysfunction variables within the 1992 ACCP/SCCM and the 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions

From: Different patient case mix by applying the 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions instead of the 1992 ACCP/SCCM sepsis definitions in surgical patients: a retrospective observational study

  ACCP/SCCM 1992 SCCM/ESICM/ACCP/ATS/SIS 2003
Diagnostic criteria for sepsis   
Infection + +
Temperature <36.0°C and/or >38.0°C <36.0°C and/or >38.3°C
Heart rate >90 >90
Respiratory rate >20 >30
White blood cell count (WBC) >12,000/μl and/or
<4,000/μl and/or
>10% immature
>12,000/μl and/or
<4,000/μl and/or
>10% immature
Altered mental status n. a. +
Significant edema n. a. +
Positive fluid balance n. a. >20 ml/kg over 24 hrs
Hyperglycemia in absence of diabetes n. a. >120 mg/dl or 7.7 mmol/l
Plasma C-reactive protein n. a. >2 SD above normal
Plasma procalcitonin n. a. >2 SD above normal
SvO2 n. a. >70%
Cardiac index n. a. >3.5 l/min/m2
Organ dysfunction variables   
Altered mental status + n. a.
Lactic acidosis + n. a.
Acute oliguria <500 ml/24 h <0.5 ml/kg/h or 45 mmol/l >2 h
Hypoperfusion or hypotension + +
SOFA score >2 n. a.
Creatinine n. a.
>3.5 mg/dl or 300 μmol/l*
n. a.
Creatinin increase n. a. >0.5 mg/dl or 43 μmol/l
Arterial hypoxemia n. a.
PaO2/FiO2 <= 200 with respiratory support*
PaO2/FiO2 < 300
Coagulation abnormalities n. a. INR > 1.5 or aPTT > 60s
Ileus (absent bowel sounds) n. a. +
Thrombocytopenia, platelet count n. a.
<= 50,000/μl*
<100,000/μl
Hyperbilirubinemia, plasma total bilirubin n. a.
>6 mg/dl or 102 μmol/l*
>4 mg/dl or 70
μmol/l
Hyperlactatemia n. a. >1 mmol/l
  1. n. a. = not applicable, INR = International Normalized Ratio, PaO2/FiO2 = partial pressure of arterial oxygen/fraction of inspired oxygen, SOFA = Sequential Organ Failure Assessement, SvO2 = mixed venous oxygen saturation, *according to the definition of organ dysfunction with greater than 2 points in the SOFA score.