The first-year growth response to growth hormone treatment predicts the long-term prepubertal growth response in children

Table 1 The characteristics of the children included in the model group (n = 162) and in the validation group (n = 205).

	Model group (30 girls, 132 boys)				Validation group (58 girls, 147 boys)
Variables	Median	Min	Max	n	Median	Min	Max	n
At birth
Gestational age (weeks)	40	37	42	162	40	37	42	205
Height at birth SDS	-1.07	-2.65	2.6	162	-1.48	-5.75	1.9	205
Weight at birth SDS	-0.88	-2.75	3.24	162	-1.28	-4.5	1.81	205
At GH start
Age at start of GH treatment (yrs)	8.3	2.78	13.92	162	7.78	2.51	12.53	205
Height SDS	-2.91	-4.59	-1.54	162	-2.84	-4.76	-1.29	205
Weight SDS	-2.58	-4.29	0.73	162	-2.5	-5.28	1.28	205
Weight for height SDS	-0.54	-3.31	3.85	162	-0.61	-3.08	4.09	205
Body mass index (kg/m²)	15.4	12.88	23.98	162	15.19	12.25	23.76	205
Change in height SDS during pre-treatment year	0.02	-0.85	0.58	144	0.01	-0.71	0.68	186
Target height SDS	-0.75	-2.4	1.26	162	-0.66	-2.71	0.94	205
Fathers height SDS	-1.13	-4.93	1.91	162	-0.83	-3.86	2.02	205
Mothers height SDS	-1,25	-3.55	1.22	162	-1.25	-3.55	1.55	205
Diff MPH SDS	-2.26	-4.98	-0.8	162	-2.27	-5.11	-0.41	205
GH_max during AITT (mU/L)	19.8	1.7	229.4	160	21	2.4	124.88	181
GH_max of 24 h profile (mU/L)	34.65	3.88	81.08	64	32.8	7.55	235.37	94
IGF-I at GH start	96.25	11.68	219	68	80	8	330	150
IGF-I SDS	-0.6	-6.69	1.38	68	-1.1	-7.43	3.03	150
GH dose (ug/kg.day)	0.033	0.027	0.04	162	0.033	0.023	0.043	205
During treatment
Change in height SDS first yr	0.72	0.3	2.26	162	0.74	0.07	2.56	205
Change in height SDS during 2 yrs	1.15	0.4	2.88	162	1.14	0.23	3.12	205

Growth hormone (mU/L) levels were analysed at GP-GRC, GU, with Delfia monoclonal assay, Wallac, Finland, standard WHO IRP 80/505, [8].
Insulin-like growth factor I (IGF-I) (μg/L) were analysed according to Blum and Breier [26] and transformed into SD scores (SDS) according to gender and age of our prepubertal reference [27].

ISSN: 1472-6947