Figure 3

Thresholds according to risk with standard treatment for a range of hypothetical benefits (reduction in relative risk, RR) and harms associated with a more aggressive treatment. 1. benefit 30%, harm = 5%, threshold = 17% (- - -), 2. benefit 40%, harm = 5%, threshold = 12.5% (--), 3. benefit 10%, harm = 1%, threshold = 12.5% (--), 4. benefit 50%, harm = 20%, threshold = 40% (----).