Models predicting the growth response to growth hormone treatment in short children independent of GH status, birth size and gestational age

Table 4 SD_res results in the total Model group (left) and total Validation group (right) giving the first, second and third year response. SDstandRes gives the ratio SDres/SDresModelgroup, 2cm 3 y gives the 2 SD prediction interval in cm at 3 years of age and 2cm 7 y gives this interval at 7 years of age.

	Model group					Validation group
Models	n	SD_res	SDstand_Res	2*cm 3 y	2*cm 7 y	n	SD_res
1 yr response
A. Auxological model	415	0.231	1	1.7	2.4	112	0.230
B. Auxological+endocrine models
IGF+leptin	199	0.191	1	1.4	2.0	82	0.209
GH_AITT+IGF+leptin	172	0.191	1	1.4	2.0	71	0.205
GH_{24 h}	188	0.164	1	1.2	1.7	60	0.165
GH_{24 h}+IGF+leptin	140	0.154	1	1.1	1.6	51	0.156
2 yrs response
A. Auxological model	305	0.340	1	2.5	3.5	77	0.351
B. Auxological+endocrine models
IGF+leptin	154	0.266	1	1.9	2.7	55	0.290
GH_AITT+IGF+leptin	138	0.260	1	1.9	2.7	45	0.280
GH_{24 h}	133	0.276	1	2.0	2.8	43	0.289
GH_{24 h}+IGF+leptin	105	0.246	1	1.8	2.5	34	0.261
3 yrs response
A. Auxological model	191	0.432	1	3.2	4.5	27	0.470
B. Auxological+endocrine models
IGF+leptin	109	0.327	1	2.4	3.4	17	0.370
GH_AITT+IGF+leptin	98	0.329	1	2.4	3.4	12	0.358
GH_{24 h}	86	0.353	1	2.6	3.6	14	0.400
GH_{24 h}+IGF+leptin	73	0.305	1	2.2	3.1	9	0.343

ISSN: 1472-6947