At birth
| | | | | | | | | | |
Gestational age (weeks)
|
39.6
|
1.3
|
37
|
42
|
415
|
39.5
|
1.5
|
37
|
42
|
112
|
Height SDS
|
-1.33
|
1.29
|
-5.8
|
2.0
|
415
|
-1.31
|
1.12
|
-5.4
|
1.5
|
112
|
Weight SDS
|
-1.08
|
1.27
|
-4.5
|
3.2
|
415
|
-1.07
|
1.1
|
-4.4
|
2.3
|
112
|
Pretreatment
| | | | | | | | | | |
Δheight SDS during pretreat yr
|
0.01
|
0.18
|
-0.5
|
0.6
|
377
|
0.03
|
0.22
|
-0.66
|
0.68
|
101
|
GHmax of GH-profile
|
42.5
|
28.8
|
3.9
|
235.4
|
188
|
34.0
|
21.3
|
7.6
|
98.1
|
60
|
GHmax during AITT
|
28.6
|
24.4
|
1.7
|
229.4
|
387
|
21.9
|
14.5
|
1.4
|
76.1
|
95
|
At GH start
| | | | | | | | | | |
SEX (min = girls, max = boys)
| | |
93
|
322
|
415
| | |
33
|
79
|
112
|
Age (yrs)
|
8.72
|
2.41
|
3.1
|
13.9
|
415
|
7.88
|
2.19
|
2.8
|
12.2
|
112
|
Height SDS
|
-2.87
|
0.6
|
-5.0
|
-1.2
|
415
|
-2.77
|
0.53
|
-4.2
|
-1.6
|
112
|
Weight SDS
|
-2.56
|
0.94
|
-6.2
|
1.8
|
415
|
-2.38
|
1.09
|
-4.9
|
2.6
|
112
|
Father height SDS
|
-1.03
|
1.07
|
-4.9
|
2.1
|
415
|
-0.74
|
1.03
|
-3.0
|
1.7
|
112
|
Mother height SDS
|
-1.31
|
1
|
-3.8
|
1.6
|
415
|
-0.99
|
0.96
|
-3.1
|
1.5
|
112
|
Diff SDS
|
-2.17
|
0.74
|
-5.0
|
-0.3
|
415
|
-2.29
|
0.72
|
-5.1
|
0.2
|
112
|
IGF SDS
|
-1.11
|
1.55
|
-7.4
|
3.0
|
223
|
-1.23
|
1.5
|
-5.3
|
2.7
|
83
|
Leptin (ng/mL)
|
3.48
|
2.37
|
1.0
|
27.8
|
216
|
3.97
|
3.75
|
1.7
|
24.1
|
82
|
During treatment
| | | | | | | | | | |
GH dose (IU/kg/day)
|
0.11
|
0.03
|
0.07
|
0.25
|
415
|
0.11
|
0.02
|
0.08
|
0.2
|
112
|
Change in height SDS 1st yr
|
0.75
|
0.3
|
0.1
|
2.3
|
415
|
0.73
|
0.25
|
0.1
|
1.6
|
112
|
Change in height SDS two yrs
|
1.18
|
0.44
|
0.2
|
3.0
|
300
|
1.17
|
0.34
|
0.4
|
2.1
|
73
|
|
c. Model group
|
d. Validation group
|
At birth
| | | | | | | | | | |
Gestational age (weeks)
|
39.4
|
1.3
|
37
|
42
|
140
|
39.6
|
1.4
|
37
|
42
|
51
|
Height SDS
|
-1.77
|
1.35
|
-5.8
|
1.9
|
140
|
-1.33
|
1.12
|
-4.1
|
1.5
|
51
|
Weight SDS
|
-1.39
|
1.36
|
-4.5
|
2.4
|
140
|
-1.19
|
1.02
|
-3.2
|
1.0
|
51
|
Pretreatment
| | | | | | | | | | |
Δheight SDS during pretreat yr
|
0.07
|
0.17
|
-0.5
|
0.6
|
135
|
0.04
|
0.18
|
-0.6
|
0.4
|
48
|
GHmax of GH-profile
|
44.3
|
28.1
|
9.3
|
235.4
|
140
|
30.6
|
17.3
|
6.4
|
76.1
|
40
|
GHmax during AITT
|
37.6
|
22.4
|
3.0
|
124.9
|
113
|
36.7
|
21.9
|
7.6
|
98.1
|
51
|
At GH start
| | | | | | | | | | |
SEX (min = girls, max = boys)
| | |
32
|
108
|
140
| | |
18
|
33
|
51
|
Age (yrs)
|
8.66
|
2.34
|
3.3
|
12.9
|
140
|
7.88
|
2.05
|
3.4
|
11.9
|
51
|
Height SDS
|
-2.86
|
0.61
|
-4.8
|
-1.7
|
140
|
-2.80
|
0.56
|
-4.2
|
-2.0
|
51
|
Weight SDS
|
-2.61
|
1.02
|
-5.3
|
1.6
|
140
|
-2.46
|
1.11
|
-4.9
|
1.3
|
51
|
Father height SDS
|
-1.04
|
1.08
|
-4.9
|
1.9
|
140
|
-0.71
|
0.91
|
-2.2
|
1.7
|
51
|
Mother height SDS
|
-1.39
|
1.04
|
-3.8
|
1.2
|
140
|
-0.88
|
0.87
|
-2.6
|
1.0
|
51
|
Diff SDS
|
-2.12
|
0.74
|
-4.6
|
-0.4
|
140
|
-2.37
|
0.77
|
-5.1
|
-0.8
|
51
|
IGF SDS
|
-0.82
|
1.32
|
-5.1
|
3.0
|
140
|
-1.49
|
1.54
|
-5.3
|
1.4
|
51
|
Leptin (ng/mL)
|
3.51
|
2.71
|
1.1
|
27.8
|
140
|
3.70
|
3.30
|
1.7
|
21.8
|
51
|
During treatment
| | | | | | | | | | |
GH dose (IU/kg/day)
|
0.12
|
0.04
|
0.07
|
0.25
|
140
|
0.12
|
0.02
|
0.08
|
0.20
|
51
|
Change in height SDS 1st yr
|
0.68
|
0.21
|
0.2
|
1.4
|
140
|
0.77
|
0.23
|
0.4
|
1.6
|
51
|
Change in height SDS two yrs
|
1.06
|
0.32
|
0.2
|
1.9
|
104
|
1.21
|
0.33
|
0.7
|
2.1
|
34
|