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Table 1 Characteristics of all children in the Model and Validation groups. The data presented for the Auxological model (a & b) and the Endocrine models (c & d).

From: Models predicting the growth response to growth hormone treatment in short children independent of GH status, birth size and gestational age

  a. Model group b. Validation group
Variables Mean SD Min Max N Mean SD Min Max N
At birth           
   Gestational age (weeks) 39.6 1.3 37 42 415 39.5 1.5 37 42 112
   Height SDS -1.33 1.29 -5.8 2.0 415 -1.31 1.12 -5.4 1.5 112
   Weight SDS -1.08 1.27 -4.5 3.2 415 -1.07 1.1 -4.4 2.3 112
Pretreatment           
   Δheight SDS during pretreat yr 0.01 0.18 -0.5 0.6 377 0.03 0.22 -0.66 0.68 101
   GHmax of GH-profile 42.5 28.8 3.9 235.4 188 34.0 21.3 7.6 98.1 60
   GHmax during AITT 28.6 24.4 1.7 229.4 387 21.9 14.5 1.4 76.1 95
At GH start           
   SEX (min = girls, max = boys)    93 322 415    33 79 112
   Age (yrs) 8.72 2.41 3.1 13.9 415 7.88 2.19 2.8 12.2 112
   Height SDS -2.87 0.6 -5.0 -1.2 415 -2.77 0.53 -4.2 -1.6 112
   Weight SDS -2.56 0.94 -6.2 1.8 415 -2.38 1.09 -4.9 2.6 112
   Father height SDS -1.03 1.07 -4.9 2.1 415 -0.74 1.03 -3.0 1.7 112
   Mother height SDS -1.31 1 -3.8 1.6 415 -0.99 0.96 -3.1 1.5 112
   Diff SDS -2.17 0.74 -5.0 -0.3 415 -2.29 0.72 -5.1 0.2 112
   IGF SDS -1.11 1.55 -7.4 3.0 223 -1.23 1.5 -5.3 2.7 83
   Leptin (ng/mL) 3.48 2.37 1.0 27.8 216 3.97 3.75 1.7 24.1 82
During treatment           
   GH dose (IU/kg/day) 0.11 0.03 0.07 0.25 415 0.11 0.02 0.08 0.2 112
   Change in height SDS 1st yr 0.75 0.3 0.1 2.3 415 0.73 0.25 0.1 1.6 112
   Change in height SDS two yrs 1.18 0.44 0.2 3.0 300 1.17 0.34 0.4 2.1 73
  c. Model group d. Validation group
At birth           
   Gestational age (weeks) 39.4 1.3 37 42 140 39.6 1.4 37 42 51
   Height SDS -1.77 1.35 -5.8 1.9 140 -1.33 1.12 -4.1 1.5 51
   Weight SDS -1.39 1.36 -4.5 2.4 140 -1.19 1.02 -3.2 1.0 51
Pretreatment           
   Δheight SDS during pretreat yr 0.07 0.17 -0.5 0.6 135 0.04 0.18 -0.6 0.4 48
   GHmax of GH-profile 44.3 28.1 9.3 235.4 140 30.6 17.3 6.4 76.1 40
   GHmax during AITT 37.6 22.4 3.0 124.9 113 36.7 21.9 7.6 98.1 51
At GH start           
   SEX (min = girls, max = boys)    32 108 140    18 33 51
   Age (yrs) 8.66 2.34 3.3 12.9 140 7.88 2.05 3.4 11.9 51
   Height SDS -2.86 0.61 -4.8 -1.7 140 -2.80 0.56 -4.2 -2.0 51
   Weight SDS -2.61 1.02 -5.3 1.6 140 -2.46 1.11 -4.9 1.3 51
   Father height SDS -1.04 1.08 -4.9 1.9 140 -0.71 0.91 -2.2 1.7 51
   Mother height SDS -1.39 1.04 -3.8 1.2 140 -0.88 0.87 -2.6 1.0 51
   Diff SDS -2.12 0.74 -4.6 -0.4 140 -2.37 0.77 -5.1 -0.8 51
   IGF SDS -0.82 1.32 -5.1 3.0 140 -1.49 1.54 -5.3 1.4 51
   Leptin (ng/mL) 3.51 2.71 1.1 27.8 140 3.70 3.30 1.7 21.8 51
During treatment           
   GH dose (IU/kg/day) 0.12 0.04 0.07 0.25 140 0.12 0.02 0.08 0.20 51
   Change in height SDS 1st yr 0.68 0.21 0.2 1.4 140 0.77 0.23 0.4 1.6 51
   Change in height SDS two yrs 1.06 0.32 0.2 1.9 104 1.21 0.33 0.7 2.1 34
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