Table 2 The input values for clinical options for lung cancer detection derived from a literature and internet search
CLINICAL OPTIONS | SN | SP | Cost($) | Reference | PMID |
|---|---|---|---|---|---|
TSGF | 0.869 | 0.911 | 100.00 | Newland Biotech [21] | N/A |
NSE | 0.4617 | 0.9323 | 100.00 | Newland Biotech [21] | N/A |
CA-125 | 0.5643 | 0.8472 | 100.00 | Newland Biotech [21] | N/A |
SELDI (serum) | 0.869 | 0.8 | 100.00 | Yang et al., 2005 [22] | 16029516 |
TLP | 0.667 | 0.8 | 100.00 | Tarro et al., 2005 [23] | 15389637 |
CA-19-9 | 0.333 | 1 | 100.00 | Tarro et al., 2005 [23] | 15389637 |
CYFRA 21-1 | 0.111 | 1 | 100.00 | Tarro et al., 2005 [23] | 15389637 |
CEA | 0 | 1 | 100.00 | Tarro et al., 2005 [23] | 15389637 |
anti-Rc | 0.2 | 0.98 | 100.00 | Bazhin et al., 2004 [24] | 15084384 |
LIFE bronchoscopy | 0.68 | 0.696 | 100.00 | Hirsch et al., 2001 [25] | 11562389 |
WLB bronchoscopy | 0.219 | 0.783 | 100.00 | Hirsch et al., 2001 [25] | 11562389 |
methylation in at least 1 of 5 tumor suppressor genes | 0.495 | 0.85 | 100.00 | Fujiwara et al., 2005 [26] | 15709192 |
CT-guided fine-needle aspirate biopsy | 0.82 | 1 | 100.00 | Wallace et al., 2002 [27] | 12461267 |
x-ray determinate only | 0.54 | 0.99 | 100.00 | Gavelli & Giampalma, 2000 [28] | 11147625 |
x-ray indeterminate | 0.84 | 0.9 | 100.00 | Gavelli & Giampalma, 2000 [28] | 11147625 |