Table 1 NCI Thesaurus sample concept with new subtype concept
A. Acral lentiginous melanoma (C4022)(existing concept defined with both text and description logic role relationships) | |
|---|---|
Parent: Cutaneous melanoma | |
Definition: A form of melanoma occurring most often on the plantar, palmar, subungual, and periungual skin. It presents as a pigmented macular lesion with irregular borders. Morphologically, it consists of atypical spindled and dendritic melanocytes. The epidermis is often hyperplastic and there is pagetoid infiltration of the epidermis by anaplastic cells. | |
<Other synonyms, codes, etc.> | |
Description logic role relationships Inherits some values from more general concepts, adds five new ones. | |
Anatomy roles: | |
Disease_Has_Primary_Anatomic_Site | Skin of the extremity |
Disease_Excludes_Primary_Anatomic_Site | Skin of the trunk |
Disease_Has_Normal_Tissue_Origin | Skin tissue |
Pathology & finding roles: | |
Disease_Has_Normal_Cell_Origin | Melanocyte |
Disease_Has_Abnormal_Cell | Dendritic melanoma cell |
Disease_Has_Abnormal_Cell | Spindle melanoma cell |
Disease_Has_Finding | Cutaneous involvement |
Disease_Has_Finding | Macular lesion |
Molecular abnormality roles: | |
Disease_May_Have_Molecular_Abnormality | BRAF gene mutation |
Disease_May_Have_Molecular_Abnormality | NF-2 tumor-suppressor gene inactivation |
B. Mucosal lentiginous melanoma (C48622)(subtype concept added to support CAP protocol, with new text definition and role) | |
Parent: Acral lentiginous melanoma | |
Definition: An acral lentiginous melanoma affecting mucosal surfaces. | |
<Other synonyms, codes, etc.> | |
Description logic role relationships Inherits all values from parent concept above, add one to logically distinguish this concept. | |
Additional anatomy role: | |
Disease_Has_Normal_Tissue_Origin | Mucosa |