Skip to main content

Table 5 Randomized control trials of treatments for ARDS published after 1998

From: A Markov computer simulation model of the economics of neuromuscular blockade in patients with acute respiratory distress syndrome

Author

Derdak40

Eisner41

Gattinoni42

ARDS network43

Ely44

Lagneau45

Subjects

All comers ARDS

Pneumonia ARDS

All comers ARDS

All comers ARDS

ARDS network (age <70)

Pa02/FiO2 < 200

Intervention

Ventilation-controlled or high frequency

Tidal volume 12 ml/kg or 6 ml/kg

Supine vs. prone

Placebo vs. ketoconazole

Tidal volume 12 ml/kg or 6 ml/kg

Cisatracurium 0/4 twitches or 2/4 twitches

# of subjects

147

320

304

234

729

102

Mean age (yrs)

49

51

58

53

46

56

Severity of illness

22**

84***

40*

81***

73***

41*

Pa02/FiO2

113

133

127

145

 

130

ICU days

    

19

 

Days on ventilator

21

   

10

 

In-hospital mortality

   

35%

 

45%

% with unassisted breathing at 1 mth

 

57%

 

59%

  

10 day mortality

  

25%, 21%

   

30 day mortality

52%, 37%

   

25%

 

6 mth mortality

59%, 47%

36%

59%, 63%

 

30%

 

Ventilator free days in first 28 days

   

10

  

reintubation

    

7.5%

Â