Author | Derdak40 | Eisner41 | Gattinoni42 | ARDS network43 | Ely44 | Lagneau45 |
---|---|---|---|---|---|---|
Subjects | All comers ARDS | Pneumonia ARDS | All comers ARDS | All comers ARDS | ARDS network (age <70) | Pa02/FiO2 < 200 |
Intervention | Ventilation-controlled or high frequency | Tidal volume 12 ml/kg or 6 ml/kg | Supine vs. prone | Placebo vs. ketoconazole | Tidal volume 12 ml/kg or 6 ml/kg | Cisatracurium 0/4 twitches or 2/4 twitches |
# of subjects | 147 | 320 | 304 | 234 | 729 | 102 |
Mean age (yrs) | 49 | 51 | 58 | 53 | 46 | 56 |
Severity of illness | 22** | 84*** | 40* | 81*** | 73*** | 41* |
Pa02/FiO2 | 113 | 133 | 127 | 145 | Â | 130 |
ICU days | Â | Â | Â | Â | 19 | Â |
Days on ventilator | 21 | Â | Â | Â | 10 | Â |
In-hospital mortality | Â | Â | Â | 35% | Â | 45% |
% with unassisted breathing at 1 mth | Â | 57% | Â | 59% | Â | Â |
10 day mortality | Â | Â | 25%, 21% | Â | Â | Â |
30 day mortality | 52%, 37% | Â | Â | Â | 25% | Â |
6 mth mortality | 59%, 47% | 36% | 59%, 63% | Â | 30% | Â |
Ventilator free days in first 28 days | Â | Â | Â | 10 | Â | Â |
reintubation | Â | Â | Â | Â | 7.5% | Â |