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Table 7 Sensitivity analysis for uncertainties in systolic BP and TC and their measurement. The three hypothetical BPs given are adjusted by +/- 11% and the TCs by +/- 15%. A 'normal' BP of 135 mmHg systolic is assumed for the TC analysis and a 'normal' cholesterol of 5.5 mmol/l is taken for the BP analysis. Values for the predicted survival at 20 years are given.

From: Description and validation of a Markov model of survival for individuals free of cardiovascular disease that uses Framingham risk factors

  

Systolic BP mmHg (95% CI)

TC mmol/l (95% CI)

  

120 (107 – 133)

140 (125 – 155)

160 (142 – 178)

4.0 (3.4 – 4.6)

6.0 (5.1 – 6.9)

8.0 (6.8 – 9.2)

35 year old man

S

94.2 – 92.9

93.4 – 90.9

92.2 – 88.0

94.0 – 93.3

93.0 – 91.5

91.6 – 89.0

 

NS

96.0 – 95.5

95.7 – 94.6

95.2 – 93.3

95.8 – 95.6

95.5 – 94.9

95.0 – 93.9

35 year-old woman

S

95.3 – 95.3

95.3 – 95.2

95.3 – 95.1

95.4 – 95.3

95.3 – 95.2

95.2 – 94.9

 

NS

96.9 – 96.9

96.9 – 96.8

96.9 – 96.8

96.9 – 96.9

96.9 – 96.9

96.9 – 96.8

50 year old man

S

73.0 – 68.3

69.9 – 63.0

66.2 – 56.7

72.8 – 70.1

68.9 – 64.0

64.3 – 57.8

 

NS

84.9 – 82.4

83.3 – 79.2

81.2 – 74.8

84.7 – 83.4

82.8 – 79.9

80.1 – 75.5

50 year-old woman

S

79.6 – 79.3

79.4 – 78.7

79.1 – 77.7

79.9 – 79.6

79.4 – 78.5

78.5 – 76.7

 

NS

89.1 – 89.0

89.0 – 88.8

88.9 – 88.5

89.2 – 89.1

89.0 – 88.7

88.7 – 88.0

65 year old man

S

16.8 – 14.7

15.4 – 12.7

13.9 – 10.6

16.8 – 15.5

14.9 – 13.1

13.2 – 11.2

 

NS

50.3 – 46.4

47.8 – 42.3

44.8 – 37.5

50.3 – 48.8

47.0 – 43.0

43.2 – 38.2

65 year-old woman

S

37.1 – 36.7

36.9 – 36.0

36.5 – 35.1

37.7 – 37.2

36.9 – 35.6

35.7 – 33.7

 

NS

63.6 – 63.3

63.5 – 62.8

63.2 – 62.0

64.0 – 63.7

63.5 – 62.5

62.6 – 60.7

  1. S = Smoker NS = Non-smoker