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Table 1 Coexpressed gene sets shared by more than 7 brain diseases.

From: Discovering transnosological molecular basis of human brain diseases using biclustering analysis of integrated gene expression data

Brain diseases sharing gene sets

Avg. PCC

Diff significance*

Genes

AD

ALS

HD

MS

PD

SCH

BD

AUT

Brain disease

Normal

P-value

Benjamini

 

1

1

1

1

1

1

1

1

0.908

0.509

1.30E-03

4.804E-03

AKR1D1, FKTN

1

1

1

1

1

1

0

1

0.854

0.084

4.00E-05

8.759E-04

LUC7L2, SULT1A1

1

1

1

1

1

1

0

1

0.884

0.343

4.20E-04

2.791E-03

ARHGEF3, ATP1A1

1

1

1

1

1

1

0

1

0.711

0.184

4.70E-04

2.977E-03

CROCC, PDE9A

1

1

1

1

1

1

0

1

0.879

0.431

9.60E-04

4.301E-03

C16orf45, RBFOX1

1

1

1

1

1

1

0

1

0.813

0.368

9.80E-04

4.301E-03

PIAS2, PRKAR1B

1

1

1

1

1

1

0

1

0.820

0.417

1.27E-03

4.790E-03

RPL19, RPL39

1

1

1

1

1

1

1

0

0.800

0.404

1.32E-03

4.828E-03

ATP6V1D, KLC1

  1. * Diff. significance: Statistical significance of the avg. PCC brain disease - avg. PCC normal empirically calculated based on the background distribution of 100,000 random gene groups.