TY - JOUR AU - Wang, Shuang AU - Mohammed, Noman AU - Chen, Rui PY - 2014 DA - 2014/12/08 TI - Differentially private genome data dissemination through top-down specialization JO - BMC Medical Informatics and Decision Making SP - S2 VL - 14 IS - 1 AB - Advanced sequencing techniques make large genome data available at an unprecedented speed and reduced cost. Genome data sharing has the potential to facilitate significant medical breakthroughs. However, privacy concerns have impeded efficient genome data sharing. In this paper, we present a novel approach for disseminating genomic data while satisfying differential privacy. The proposed algorithm splits raw genome sequences into blocks, subdivides the blocks in a top-down fashion, and finally adds noise to counts to preserve privacy. The experimental results suggest that the proposed algorithm can retain certain data utility in terms of a high sensitivity. SN - 1472-6947 UR - https://doi.org/10.1186/1472-6947-14-S1-S2 DO - 10.1186/1472-6947-14-S1-S2 ID - Wang2014 ER -