Table 8 Comparison of mined drug adverse reactions with those reported in drug package inserts

Lisinopril

High blood pressure

Headache, dizziness, cough,

Cough (12.57%), dizziness (2.77%),

Hearing loss (0.53%), hair

(hypertension),

fatigue, rash, diarrhea, nausea,

headache (1.81%), fatigue (1.49%),

loss (0.53%), shingles (0.43%),

congestive heart failure,

cramps

cramps (1.38%), diarrhea (0.96%),

fits (0.32%)

improve survival after a

nausea (0.75%), rash (0.43%)

heart attack

Prednisone

Allergic disorders,

Anxiety, dizziness, depression,

Anxiety (5.57%), insomnia (3.15%),

Hives (1.3%), acid reflux

skin conditions,

insomnia, headache, nausea,

depression (2.97%), dizziness (2.41%),

(0.37%), avascular necrosis

ulcerative colitis,

moon face, elevation in blood

mood swings (2.41%), weight gain

(0.37%), dry mouth (0.37%),

arthritis, lupus,

pressure, behavioral and

(1.86%), nausea (1.3%), moon face

breathing disorders

mood changes, weight gain

(1.11%)

Singulair

Asthma, allergic rhinitis

Upper respiratory infection,

Headache (2.02%), infection (1.12%),

Seizure (6.28%), depression

fever, headache, pharyngitis,

cough (1.12%), fever (0.90%),

(3.59%), nightmares (3.36%),

cough, abdominal pain,

diarrhea (0.45%), sinusitis (0.45%),

aggression (2.91%), mood

diarrhea, influenza,

inflammation (0.45%)

swings (2.02%), suicide

rhinorrhea, sinusitis

(1.35%), suicidal thoughts

(0.9%)

Topamax

Seizures, migraine

Anorexia, paresthesia (tingling),

Tingling (5.64%), weight loss (4.14%),

Hair loss (3.01%), depression

headaches

fatigue, nervousness, weight

memory loss (3.76%), numbness

(2.26%), stress (1.88%),

decrease, somnolence,

(2.26%), dizziness (2.26%), tired

aches (1.88%), anxiety (1.13%),

dizziness, infection, flushing,

(1.88%), sleepy (1.13%)

diarrhea (1.13%), dry mouth

psychomotor slowing,

(1.13%), itching (1.13%)

difficulty with memory

Drug Name

Prescribed for

Common ADRs in

Common ADRs mined

Novel side-effects mined

Drug Package Inserts

from steadyhealth.com

from steadyhealth.com

Adderall

Narcolepsy and

Palpitations, elevation of blood

Depression (6.04%), weight loss

Anxiety (4.53%), fatigue

attention deficit

pressure, sudden death,

(5.10%), headache (3.97%), dizziness

(3.39%), addiction (2.45%),

hyperactivity

myocardial infarction, dryness

(2.64%), dry mouth (1.70%), insomnia

mood swings (1.89%),

disorder (ADHD)

of the mouth, diarrhea, weight

(1.51%), constipation (1.13%), loss

vomiting (1.32%), nausea

loss, constipation, rash,

of appetite (1.13%), death (0.94%),

(1.13%), hallucinations

restlessness, dizziness,

seizures (0.75%), high blood

(0.75%)

insomnia, depression,

pressure (0.57%), restlessness (0.57%)

headache, seizures

Cortisone

Allergic disorders,

Allergic reactions, cardiac

Headache (2.37%), allergies (1.97%),

Anxiety (2.96%), cramps

skin conditions,

arrest, hypertension, acne,

nausea (1.97%), weight gain (1.97%),

(2.57%), bleeding (2.37%),

ulcerative colitis,

cutaneous and subcutaneous

depression (1.58%), insomnia (1.38%),

bleeding (2.37%), back pain

arthritis, lupus,

atrophy rash, increased

high blood pressure (1.38%), acne

(2.17%), dizziness (1.97%),

psoriasis, or

appetite, depression, mood

(1.18%), atrophy (0.99%), rash (0.79%)

numbness (1.18%), diarrhea

breathing disorders

swings, nausea, headache,

(0.99%)

insomnia, weight gain

Effexor

Major depressive

Insomnia, dizziness, dry mouth,

Dizziness (6.07%), headache (3.35%),

Weight gain (3.97%), acne

disorder, anxiety,

nausea, headache, sweating,

nausea (2.09%), sweating (1.26%),

(1.26%), shocks (1.26%),

and panic disorder

chills, vomiting, diarrhea,

insomnia (1.05%), vomiting (1.05%),

hives (1.05%), mood swings

tachycardia

chills (1.05%), diarrhea (1.05%),

(0.84%)

tachycardia (0.84%)

Suboxone

Narcotic (opiate)

Headache, vomiting, nausea,

Pain (17.23%), insomnia (2.7%),

Anxiety (5.07%), tired (4.39%),

addiction

hyperhidrosis (sweating),

depression (2.7%), chronic pain (2.03%),

restlessness (4.05%), chills

insomnia, constipation, pain,

sweats (2.02%), headaches (1.01%)

(3.72%), weight gain (1.69%),

depression and peripheral

runny nose (1.35%)

edema