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Table 5 Multivariable cox regression fit on BRCA2 data set, overall and stratified by menopausal stage, with covariate set based on model (ii)

From: Can multiple SNP testing in BRCA2 and BRCA1 female carriers be used to improve risk prediction models in conjunction with clinical assessment?

Variable BRCA2
  All subjects Menopause Ovulating
  AIC = 3137 AIC = 881 AIC = 475
  PH p-value = 0.03497 PH p-value = 0.00125 PH p-value = 0.11892
  RH (95% CI) p-value RH (95% CI) p-value RH (95% CI) p-value
Year of birth 1.07 (1.05-1.08) >0.0001 1.07 (1.04-1.11) >0.0001 1.06 (1.02-1.09) 0.0005
Manchester score 1.04 (0.76-1.43) 0.8048 1 (0.61-1.65) 0.9862 1.49 (0.56-3.98) 0.4228
GPS 1.33 (1.1-1.61) 0.0038 1.33 (0.93-1.91) 0.119 0.88 (0.51-1.51) 0.6416
BMI 0.99 (0.94-1.03) 0.5491 0.99 (0.92-1.06) 0.6694 1.03 (0.92-1.16) 0.5714
Parity q2 vs. q1 0.9 (0.66-1.24) 0.5307 1.4 (0.73-2.67) 0.3096 1.06 (0.38-2.99) 0.9083
Parity q3 vs. q1 0.89 (0.6-1.34) 0.5817 1.01 (0.46-2.21) 0.9808 1.51 (0.36-6.31) 0.5705
Parity q4 vs. q1 0.78 (0.47-1.28) 0.3182 0.9 (0.38-2.13) 0.8112 1.32 (0.34-5.12) 0.6914
Parity missing vs. q1 0.15 (0.06-0.38) >0.0001 N/A N/A N/A N/A
Age of menarche q2 vs. q1 1.36 (0.94-1.97) 0.1007 2.53 (1.47-4.35) 0.0008 1.57 (0.64-3.84) 0.3251
Age of menarche q3 vs. q1 1.39 (0.94-2.07) 0.0984 1.76 (0.95-3.27) 0.0742 2.43 (0.92-6.45) 0.074
Age of menarche q4 vs. q1 1.25 (0.83-1.88) 0.2822 1.51 (0.83-2.76) 0.1803 2.03 (0.79-5.25) 0.1422
Age of menarche missing vs. q1 2.32 (1.43-3.78) 0.0007 1.54 (0.18-13.15) 0.6947 1.06 (0.24-4.81) 0.9362
Age of menopause q2 vs. q1 1.16 (0.64-2.1) 0.6161 0.76 (0.39-1.48) 0.4188   
Age of menopause q3 vs. q1 0.91 (0.51-1.63) 0.7511 0.63 (0.34-1.17) 0.1429   
Age of menopause q4 vs. q1 0.9 (0.48-1.69) 0.7391 0.67 (0.33-1.37) 0.2762   
Age of menopause missing vs. q1 1.03 (0.59-1.8) 0.9114     
Age of menopause not yet* vs. q1 4.11 (2.41-7.01) >0.0001     
Age of full-term pregnancy q2 vs. q1 1.55 (1.1-2.2) 0.0133 1.52 (0.82-2.81) 0.1825 1.96 (0.69-5.57) 0.2043
Age of full-term pregnancy q3 vs. q1 1.03 (0.71-1.49) 0.8902 0.94 (0.48-1.85) 0.8659 1.61 (0.62-4.19) 0.327
Age of full-term pregnancy q4 vs. q1 0.91 (0.62-1.33) 0.6154 1.96 (1.01-3.8) 0.0471 0.6 (0.21-1.71) 0.3371
Age of full-term pregnancy missing vs. q1 1.43 (0.95-2.15) 0.0822 1.16 (0.46-2.88) 0.7546 2.64 (0.68-10.25) 0.161
Age of full-term pregnancy not yet** vs. q1 16.5 (5.32-51.21) >0.0001 N/A N/A 19.2 (3.57-103.1) 0.0006
Oral contraception usage q2 vs. q1 1 (0.64-1.54) 0.9822 1.29 (0.67-2.48) 0.4473 0.84 (0.31-2.25) 0.7241
Oral contraception usage q3 vs. q1 1.67 (1.11-2.5) 0.0129 1.8 (0.94-3.46) 0.0774 1.45 (0.58-3.63) 0.4289
Oral contraception usage q4 vs. q1 1.34 (0.85-2.1) 0.2049 1.95 (0.92-4.11) 0.0814 0.85 (0.3-2.4) 0.7582
Oral contraception usage missing vs. q1 1.08 (0.71-1.63) 0.7282 0.9 (0.46-1.74) 0.7472 1.44 (0.58-3.59) 0.4294
Mastectomy 0.05 (0.01-0.39) 0.0038 N/A N/A N/A N/A
Oophorectomy 0.18 (0.11-0.29) >0.0001 0.22 (0.13-0.38) >0.0001 N/A N/A
  1. N/A: could not be fit in the model; q1 … q4: first to fourth quartile, with the first being the youngest (~40 years old); *ovulating; **never had full term pregnancy
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