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Table 5 Multivariable cox regression fit on BRCA2 data set, overall and stratified by menopausal stage, with covariate set based on model (ii)

From: Can multiple SNP testing in BRCA2 and BRCA1 female carriers be used to improve risk prediction models in conjunction with clinical assessment?

Variable

BRCA2

 

All subjects

Menopause

Ovulating

 

AIC = 3137

AIC = 881

AIC = 475

 

PH p-value = 0.03497

PH p-value = 0.00125

PH p-value = 0.11892

 

RH (95% CI)

p-value

RH (95% CI)

p-value

RH (95% CI)

p-value

Year of birth

1.07 (1.05-1.08)

>0.0001

1.07 (1.04-1.11)

>0.0001

1.06 (1.02-1.09)

0.0005

Manchester score

1.04 (0.76-1.43)

0.8048

1 (0.61-1.65)

0.9862

1.49 (0.56-3.98)

0.4228

GPS

1.33 (1.1-1.61)

0.0038

1.33 (0.93-1.91)

0.119

0.88 (0.51-1.51)

0.6416

BMI

0.99 (0.94-1.03)

0.5491

0.99 (0.92-1.06)

0.6694

1.03 (0.92-1.16)

0.5714

Parity q2 vs. q1

0.9 (0.66-1.24)

0.5307

1.4 (0.73-2.67)

0.3096

1.06 (0.38-2.99)

0.9083

Parity q3 vs. q1

0.89 (0.6-1.34)

0.5817

1.01 (0.46-2.21)

0.9808

1.51 (0.36-6.31)

0.5705

Parity q4 vs. q1

0.78 (0.47-1.28)

0.3182

0.9 (0.38-2.13)

0.8112

1.32 (0.34-5.12)

0.6914

Parity missing vs. q1

0.15 (0.06-0.38)

>0.0001

N/A

N/A

N/A

N/A

Age of menarche q2 vs. q1

1.36 (0.94-1.97)

0.1007

2.53 (1.47-4.35)

0.0008

1.57 (0.64-3.84)

0.3251

Age of menarche q3 vs. q1

1.39 (0.94-2.07)

0.0984

1.76 (0.95-3.27)

0.0742

2.43 (0.92-6.45)

0.074

Age of menarche q4 vs. q1

1.25 (0.83-1.88)

0.2822

1.51 (0.83-2.76)

0.1803

2.03 (0.79-5.25)

0.1422

Age of menarche missing vs. q1

2.32 (1.43-3.78)

0.0007

1.54 (0.18-13.15)

0.6947

1.06 (0.24-4.81)

0.9362

Age of menopause q2 vs. q1

1.16 (0.64-2.1)

0.6161

0.76 (0.39-1.48)

0.4188

  

Age of menopause q3 vs. q1

0.91 (0.51-1.63)

0.7511

0.63 (0.34-1.17)

0.1429

  

Age of menopause q4 vs. q1

0.9 (0.48-1.69)

0.7391

0.67 (0.33-1.37)

0.2762

  

Age of menopause missing vs. q1

1.03 (0.59-1.8)

0.9114

    

Age of menopause not yet* vs. q1

4.11 (2.41-7.01)

>0.0001

    

Age of full-term pregnancy q2 vs. q1

1.55 (1.1-2.2)

0.0133

1.52 (0.82-2.81)

0.1825

1.96 (0.69-5.57)

0.2043

Age of full-term pregnancy q3 vs. q1

1.03 (0.71-1.49)

0.8902

0.94 (0.48-1.85)

0.8659

1.61 (0.62-4.19)

0.327

Age of full-term pregnancy q4 vs. q1

0.91 (0.62-1.33)

0.6154

1.96 (1.01-3.8)

0.0471

0.6 (0.21-1.71)

0.3371

Age of full-term pregnancy missing vs. q1

1.43 (0.95-2.15)

0.0822

1.16 (0.46-2.88)

0.7546

2.64 (0.68-10.25)

0.161

Age of full-term pregnancy not yet** vs. q1

16.5 (5.32-51.21)

>0.0001

N/A

N/A

19.2 (3.57-103.1)

0.0006

Oral contraception usage q2 vs. q1

1 (0.64-1.54)

0.9822

1.29 (0.67-2.48)

0.4473

0.84 (0.31-2.25)

0.7241

Oral contraception usage q3 vs. q1

1.67 (1.11-2.5)

0.0129

1.8 (0.94-3.46)

0.0774

1.45 (0.58-3.63)

0.4289

Oral contraception usage q4 vs. q1

1.34 (0.85-2.1)

0.2049

1.95 (0.92-4.11)

0.0814

0.85 (0.3-2.4)

0.7582

Oral contraception usage missing vs. q1

1.08 (0.71-1.63)

0.7282

0.9 (0.46-1.74)

0.7472

1.44 (0.58-3.59)

0.4294

Mastectomy

0.05 (0.01-0.39)

0.0038

N/A

N/A

N/A

N/A

Oophorectomy

0.18 (0.11-0.29)

>0.0001

0.22 (0.13-0.38)

>0.0001

N/A

N/A

  1. N/A: could not be fit in the model; q1 … q4: first to fourth quartile, with the first being the youngest (~40 years old); *ovulating; **never had full term pregnancy