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Table 4 Multivariable cox regression fit on BRCA1 data set, overall and stratified by menopausal stage, with covariate set based on model (ii)

From: Can multiple SNP testing in BRCA2 and BRCA1 female carriers be used to improve risk prediction models in conjunction with clinical assessment?

Variable BRCA1
  All subjects Menopause Ovulating
  AIC = 3175 AIC = 765 AIC = 591
  PH p-value > 0.0001 PH p-value = 0.0111 PH p-value = 0.5040
  RH (95% CI) p-value RH (95% CI) p-value RH (95% CI) p-value
Year of birth 1.06 (1.05-1.08) >0.0001 1.06 (1.03-1.09) >0.0001 1.08 (1.04-1.11) >0.0001
Manchester score 0.8 (0.61-1.05) 0.1013 0.35 (0.19-0.64) 0.0006 1.56 (0.83-2.91) 0.1635
GPS 0.76 (0.61-0.95) 0.0151 0.88 (0.54-1.45) 0.6248 0.58 (0.37-0.9) 0.0148
BMI 1.02 (0.98-1.06) 0.3942 1.01 (0.94-1.07) 0.844 1.13 (1.02-1.25) 0.0229
Parity q2 vs. q1 1.32 (0.91-1.89) 0.1389 1.99 (0.91-4.37) 0.0846 0.72 (0.32-1.63) 0.4298
Parity q3 vs. q1 1.21 (0.8-1.82) 0.377 1.24 (0.52-2.96) 0.6246 0.85 (0.36-2.04) 0.7228
Parity q4 vs. q1 1.61 (1.01-2.56) 0.046 1.88 (0.65-5.44) 0.2434 1.21 (0.43-3.4) 0.724
Parity missing vs. q1 1.22 (0.43-3.52) 0.7066 N/A N/A 3.16 (0.34-28.9) 0.3089
Age of menarche q2 vs. q1 1.17 (0.82-1.67) 0.3914 1.14 (0.58-2.26) 0.6979 0.43 (0.17-1.07) 0.0695
Age of menarche q3 vs. q1 1.02 (0.67-1.54) 0.9345 1.02 (0.45-2.32) 0.9638 0.87 (0.45-1.71) 0.6918
Age of menarche q4 vs. q1 0.82 (0.55-1.23) 0.3437 1.34 (0.71-2.54) 0.3682 0.94 (0.4-2.16) 0.8772
Age of menarche missing vs. q1 1.12 (0.71-1.74) 0.6307 2.63 (0.86-8.03) 0.0902 1.49 (0.58-3.81) 0.4094
Age of menopause q2 vs. q1 0.37 (0.19-0.72) 0.0036 0.19 (0.09-0.43) >0.0001   
Age of menopause q3 vs. q1 0.39 (0.22-0.7) 0.0015 0.21 (0.1-0.45) >0.0001   
Age of menopause q4 vs. q1 0.33 (0.18-0.6) 0.0003 0.13 (0.06-0.28) >0.0001   
Age of menopause missing vs. q1 0.64 (0.39-1.04) 0.0708     
Age of menopause not yet* vs. q1 4.48 (2.74-7.33) >0.0001     
Age of full-term pregnancy q2 vs. q1 1.22 (0.87-1.71) 0.2594 1.96 (0.98-3.91) 0.0576 1.06 (0.45-2.49) 0.8908
Age of full-term pregnancy q3 vs. q1 1.37 (0.96-1.96) 0.079 2.01 (0.94-4.32) 0.0734 2.06 (0.97-4.38) 0.0615
Age of full-term pregnancy q4 vs. q1 1.22 (0.81-1.84) 0.3512 2.8 (1.16-6.76) 0.0221 0.95 (0.34-2.64) 0.9163
Age of full-term pregnancy missing vs. q1 1.11 (0.7-1.79) 0.652 1.31 (0.45-3.8) 0.6245 0.98 (0.34-2.83) 0.9744
Age of full-term pregnancy not yet** vs. q1 2.17 (0.98-4.79) 0.0552 N/A N/A 2.69 (0.77-9.34) 0.1198
Oral contraception usage q2 vs. q1 0.64 (0.39-1.04) 0.0704 0.4 (0.18-0.9) 0.0263 1.14 (0.39-3.33) 0.8105
Oral contraception usage q3 vs. q1 1.07 (0.71-1.62) 0.7575 0.48 (0.23-1) 0.0495 4.77 (1.77-12.83) 0.002
Oral contraception usage q4 vs. q1 1 (0.65-1.54) 0.9936 0.98 (0.46-2.07) 0.9571 2.13 (0.82-5.54) 0.1211
Oral contraception usage missing vs. q1 1.1 (0.72-1.66) 0.6686 0.4 (0.19-0.87) 0.0207 3.94 (1.42-10.94) 0.0084
Mastectomy 0.04 (0.01-0.31) 0.0018 0.05 (0.01-0.39) 0.0044 N/A N/A
Oophorectomy 0.31 (0.16-0.58) 0.0003 0.3 (0.15-0.62) 0.0012 N/A N/A
  1. N/A: could not be fit in the model; q1 … q4: first to fourth age quartile, with the first being the youngest (~40 years old); *Ovulating; **Never had full term pregnancy.
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