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Table 3 AUROC of PPN by MedDRA top-level category

From: Concordance and predictive value of two adverse drug event data sets

MedDRA top-level category

Lexi-comp 2010

SIDER 2012

AUROC (95% CI)

AUROC (95% CI)

Nervous system disorders

0.85 (0.84 – 0.86)

0.84 (0.84 – 0.85)

Gastrointestinal disorders

0.85 (0.84 – 0.86)

0.84 (0.83 – 0.85)

Skin and subcutaneous tissue disorders

0.85 (0.84 – 0.86)

0.85 (0.85 – 0.86)

General disorders

0.86 (0.84 – 0.87)

0.76 (0.75 – 0.77)

Respiratory, thoracic and mediastinal disorders

0.80 (0.79 – 0.82)

0.78 (0.77 – 0.79)

Vascular disorders

0.84 (0.83 – 0.86)

0.83 (0.82 – 0.84)

Psychiatric disorders

0.83 (0.82 – 0.85)

0.81 (0.81 – 0.82)

Musculoskeletal and connective tissue disorders

0.82 (0.80 – 0.84)

0.83 (0.82 – 0.84)

Eye disorders

0.79 (0.77 – 0.81)

0.83 (0.82 – 0.84)

Infections and infestations

0.85 (0.83 – 0.86)

0.85 (0.84 – 0.86)

Investigations

0.86 (0.84 – 0.88)

0.80 (0.79 – 0.81)

Metabolism and nutrition disorders

0.81 (0.79 – 0.83)

0.82 (0.81 – 0.83)

Blood and lymphatic system disorders

0.87 (0.86 - 0.89)

0.88 (0.87 – 0.88)

Cardiac disorders

0.83 (0.81 – 0.85)

0.84 (0.82 – 0.85)

Renal and urinary disorders

0.86 (0.84 – 0.87)

0.85 (0.83 – 0.86)

Reproductive system and breast disorders

0.85 (0.82 – 0.87)

0.86 (0.84 – 0.87)

Immune system disorders

0.88 (0.87 – 0.90)

0.90 (0.89 – 0.91)

Neoplasms benign, malignant and unspecified

0.80 (0.74 – 0.85)

0.78 (0.76 – 0.80)

Hepatobiliary disorders

0.85 (0.83 – 0.88)

0.83 (0.81 – 0.84)

Injury, poisoning and procedural disorders

0.86 (0.84 – 0.89)

0.80 (0.78 – 0.82)

Endocrine disorders

0.82 (0.79 – 0.85)

0.85 (0.83 – 0.86)

Ear and labyrinth disorders

0.86 (0.83 – 0.89)

0.84 (0.82 – 0.86)

Surgical and medical procedures

0.82 (0.73 – 0.89)

0.66 (0.60 – 0.72)

Pregnancy, puerperium and perinatal conditions

0.78 (0.63 – 0.93)

0.74 (0.66 – 0.82)

Congenital, familial and genetic disorders

0.91 (0.83 – 0.98)

0.60 (0.53 – 0.66)

  1. Note: Rows are shown in decreasing order of the number of SIDER-only associations. Bold-face: Six MedDRA categories with the highest AUROC difference between SIDER 2012 and Lexi-comp 2010.