From: A simulation model of colorectal cancer surveillance and recurrence
Parameter | Definition | Starting range (inclusive) | Final calibrated parameter value |
---|---|---|---|
r d | Rate per 3-month cycle at which recurrences transition from undetectable to detectable | 0.05 - 0.12 | 0.092 |
x ds | Baseline (Di = 0) presymptomatic window | 1 week – 9 months | 17 weeks |
x du | Baseline (Di = 0) window of resectability | 1 week – 9 months | 6 weeks |
r s | Increment in presymptomatic window for each additional unit of Di (expressed as a rate per 3-month cycle) | −0.025 - 0.15 | 0.07 |
r u | Increment in window of resectability for each additional unit of Di (expressed as a rate per 3-month cycle) | 0 - 0.15 | 0.11 |
σ ds | Standard deviation of normally-distributed error term for presymptomatic window | 1 week – 6 months | 11 weeks |
m | Background five-year cumulative probability of mortality from non-CRC causes | 1% - 20% | 1.6%a |