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Table 2 A comparison of the results from the pipeline with those from the study of Wang et. al

From: A pipeline to extract drug-adverse event pairs from multiple data sources

BUPROPION

(Treatment indications: depression and smoking cessation aid)

 

Reference standard

Known AEs

Indication associations

Remote indication associations

Wang et. al

Constipation, dizziness, drowsiness, dry mouth, headache, pruritus, increased sweating, loss of appetite, nausea, vomiting, nervousness, restlessness, taste changes, trouble sleeping, weight changes, seizure

Dizziness, abnormal sensation, difficulty, fatigue, constipation, sleeplessness, seizure, tinnitus, pruritus, feeling suicidal, drugged state

Suicidal, visual hallucinations, moody, emotional, tremor, nightmare

Motor retardation, fall, jumpy, stiffness, early satiety, extrapyramidal sign, energy increased, malingerer, rale, urge incontinence, bulimia, yellow sputum, emaciation

Results from the pipeline

Blogs

Constipation, dizziness, drowsiness, dry mouth, headache, pruritus, eating disorders, anorexia nervosa, nausea, vomiting, shaking, hysteria, taste disorders, eating disorders, sleep deprivation, sleep initiation and maintenance disorders, sleep disorders, sleep apnea syndrome, weight loss, weight gain, overweight, weight, seizures, tinnitus, depression, major depression, stress disorders post-traumatic, anxiety

Dizziness, fatigue, constipation, sleep deprivation, sleep initiation and maintenance disorders, sleep disorders, sleep apnea syndrome, seizures, tinnitus, pruritus, depression, major depression, stress disorders post-traumatic, anxiety

Depression, major depression, stress disorders post-traumatic, anxiety, hallucinations, mood disorders, tremor, bad dreams, vivid dreams

Psychomotor agitation, eating disorders, weight loss

MEDLINE Abstracts

Constipation, dizziness, sleepiness, dry mouth, headache, pruritus, aquagenic pruritus, brachioradial pruritus, generalized pruritus, sweating, eating disorders, increased appetite, nausea, nausea and vomiting, vomiting, restless legs syndrome, taste disorders, taste disturbance, sleep deprivation, sleep initiation and maintenance disorders, sleep disorders, sleep apnea syndromes, sleep disturbances, sleep maintenance insomnia, sleep arousal disorders, loss of weight, weight increase, overweight, weight, body weight changes, seizures, atonic seizures, complex partial seizures, psychomotor seizures, alcohol withdrawal seizures, partial seizures, neonatal seizures, seizures febrile, tinnitus, suicidal behavior, suicidal ideation

Dizziness, sensation disorders, voiding difficulty, fatigue, mental fatigue, fatigue syndrome chronic, constipation, sleep deprivation, sleep initiation and maintenance disorders, sleep disorders, sleep apnea syndromes, sleep disturbances, sleep maintenance insomnia, sleep arousal disorders, seizures, atonic seizures, complex partial seizures, psychomotor seizures, alcohol withdrawal seizures, partial seizures, neonatal seizures, seizures febrile, tinnitus, pruritus, suicidal behavior, suicidal ideation, drug toxicity, drug-specific antibodies, drug screen, abnormalities drug-induced, drug diversion, drug intolerance, drug-induced headache, drug-induced lupus erythematosus, drug seeking behavior, drug overdose, akathisia drug-induced, dyskinesia drug-induced, multiple-drug resistance, fixed drug eruption, extensively drug-resistant tuberculosis, drug eruptions, drug-induced liver injury, drug resistance, drug hypersensitivity

Suicidal behavior, suicidal ideation, hallucinations, mood disorders, mood swings, depressed mood, emotional liability, tremor, holmes tremor, essential tremor, nightmares

Psychomotor agitation, psychomotor retardation, psychomotor disorders, peripheral sensorimotor neuropathy, psychomotor seizures, epilepsy partial motor, motor fluctuations, rhinitis vasomotor, oculomotor nerve diseases, fall, fear of falling, extrapyramidal symptoms, moist rales, urinary urgency, urination disorders, urinary bladder overactive, bulimia, bulimia nervosa, binge-eating disorder, eating disorders, sputum, weight loss, loss of weight

AERS

Constipation, dizziness, dizziness postural, dry mouth, lip dry, headache, pruritus, pruritus generalised, pruritus genital, instillation site pruritus, application site pruritus, ear pruritus, vulvovaginal pruritus, anal pruritus, eye pruritus, infusion site pruritus, injection site pruritus, night sweats, cold sweat, decreased appetite, appetite disorder, increased appetite, nausea, vomiting, vomiting neonatal, nervousness, restlessness, restless legs syndrome, eating disorder, product taste abnormal, sleep disorder, sleep apnoea syndrome, rapid eye movements sleep abnormal, sleep terror, irregular sleep phase, sleep phase rhythm disturbance, abnormal sleep-related event, poor quality sleep, weight decreased, weight increased, overweight, weight abnormal, weight loss poor, atonic seizures, complex partial seizures, partial seizures, tinnitus, depression suicidal, suicidal ideation, suicide attempt, suicidal behaviour

Dizziness, dizziness postural, abnormal sensation in eye, burning sensation, fatigue, constipation, sleep disorder, sleep apnoea syndrome, rapid eye movements sleep abnormal, sleep terror, irregular sleep phase, sleep phase rhythm disturbance, abnormal sleep-related event, poor quality sleep, atonic seizures, complex partial seizures, partial seizures, tinnitus, pruritus, pruritus generalised, pruritus genital, instillation site pruritus, application site pruritus, ear pruritus, vulvovaginal pruritus, anal pruritus, eye pruritus, infusion site pruritus, injection site pruritus, suicidal behaviour, depression suicidal, suicide attempt, suicidal ideation, drug intolerance, drug hypersensitivity, drug interaction, intentional drug misuse, drug withdrawal syndrome

Suicidal behaviour, depression suicidal, suicide attempt, suicidal ideation, completed suicide, hallucination visual, hallucination, hallucination olfactory, hallucination auditory, hallucinations mixed, hypnagogic hallucination, mood swings, depressed mood, elevated mood, mood altered, euphoric mood, emotional disorder, emotional distress, tremor, essential tremor, intention tremor, parkinsonian rest tremor, nightmare, abnormal dreams

Motor dysfunction, psychomotor retardation, psychomotor hyperactivity, fall, fear of falling, musculoskeletal stiffness, joint stiffness, early satiety, extrapyramidal disorder, energy increased, rales, incontinence, defaecation urgency, urinary incontinence, hypotonic urinary bladder, faecal incontinence, bulimia nervosa, binge eating, eating disorder, sputum discoloured, weight decreased, weight abnormal