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Table 1 Supporting evidence for combination drug simulation result.

From: Rule-based multi-scale simulation for drug effect pathway analysis

Drug A Drug B Drug development State
Metformin Saxagliptin FDA approved
Metformin Sitagliptin FDA approved
Metformin Vildagliptin FDA approved
Metformin Miglitol Literature [26]
Metformin Voglibose FDA approved
Metformin Liraglutide Phase 3
Metformin Mitiglinide Phase 3
Metformin Nateglinide Literature [27]
Metformin Repaglinide FDA approved
Metformin Glipizide FDA approved
Metformin Gliquidone Literature [28]
Metformin Glimepiride FDA approved
Metformin Glyburide FDA approved
Metformin Pioglitazone FDA approved
Metformin Rosiglitazone FDA approved
  1. We simulated twenty-one pairs of combination drug that consisted with metformin. It was identified that the sixteen among twenty-one pairs of combination drug have efficacy. Fifteen pairs of combination drug have strong evidence of efficacy from previous clinical studies: ten pairs are FDA-approved and two pairs are in clinical trials. And also three pairs have been investigated in several literatures [2628].
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