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Table 1 Supporting evidence for combination drug simulation result.

From: Rule-based multi-scale simulation for drug effect pathway analysis

Drug A

Drug B

Drug development State

Metformin

Saxagliptin

FDA approved

Metformin

Sitagliptin

FDA approved

Metformin

Vildagliptin

FDA approved

Metformin

Miglitol

Literature [26]

Metformin

Voglibose

FDA approved

Metformin

Liraglutide

Phase 3

Metformin

Mitiglinide

Phase 3

Metformin

Nateglinide

Literature [27]

Metformin

Repaglinide

FDA approved

Metformin

Glipizide

FDA approved

Metformin

Gliquidone

Literature [28]

Metformin

Glimepiride

FDA approved

Metformin

Glyburide

FDA approved

Metformin

Pioglitazone

FDA approved

Metformin

Rosiglitazone

FDA approved

  1. We simulated twenty-one pairs of combination drug that consisted with metformin. It was identified that the sixteen among twenty-one pairs of combination drug have efficacy. Fifteen pairs of combination drug have strong evidence of efficacy from previous clinical studies: ten pairs are FDA-approved and two pairs are in clinical trials. And also three pairs have been investigated in several literatures [26–28].