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Table 1 Literature analysis result.

From: Generation and application of drug indication inference models using typed network motif comparison analysis

Rank Chemical Name CasRN Literature Title
1 Cyclosporine 59865-13-3 The concentration of cyclosporine metabolites is significantly lower in kidney transplant recipients with diabetes mellitus. [17]
2 Heparin 9005-49-6 Diabetes Mellitus, Glycoprotein IIb/IIIa Blockade, and Heparin. [18]
3 Cholecalciferol 67-97-0 Effect of cholecalciferol supplementation on blood glucose in an experimental model of type 2 diabetes mellitus in spontaneously hypertensive rats and Wistar rats. [19]
4 Azacitidine 320-67-2 Newly inferred indication.
5 Cysteine 52-90-4 Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. [20]
6 Chenodeoxycholic Acid 474-25-9 In the search for specific inhibitors of human 11beta-hydroxysteroid-dehydrogenases (11beta-HSDs): chenodeoxycholic acid selectively inhibits 11beta-HSD-I. [21]
7 Diethylstilbestrol 56-53-1 The effect of diethylstilbestrol upon alloxan diabetes in the male rat. [22]
8 Tretinoin 302-79-4 Newly inferred indication.
9 Daunorubicin 20830-81-3 Newly inferred indication.
10 Ursodeoxycholic Acid 128-13-2 Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes. [23]
  1. Related literatures for the top 10 highest scored indications of 'T2DM' from enhanced4-node TNMCA model. Cycloporine [17], Heparin [18], Cholecalciferol [19], Cycteine [20], Chenodeoxycholic Acid [21], Diethylstilbestrol [22], and Ursodeoxycholic Acid [23] were reported to have interactions with 'T2DM'.