Table 1 Comparison of the demographic and clinical characteristics of the COPD patients with very poor or typical HRQoL measured with the generic 15D instrument
From: Bayesian predictors of very poor health related quality of life and mortality in patients with COPD
Characteristics | Very poor HRQoL N = 152 | Typical HRQoL N = 587 | P value |
|---|---|---|---|
Male gender, N (%)1 | 93 (61.2) | 377 (65.1) | 0.4 |
Age, mean in years (±SD) 2 | 63.6 (7.0) | 64.1 (6.8) | 0.3 |
Duration of COPD, mean in years (±SD) 2 | 6.4 (4.3) | 5.3 (5.0) | 0.002 |
Age at asthma onset, mean in years (±SD) 2 | 52.8 (7.3) | 57.6 (7.3) | 0.002 |
Age at COPD onset, mean in years (±SD) 2 | 57.6 (7.6) | 58.4 (7.3) | 0.2 |
Pack years, mean (±SD) 2 | 49 (19) | 51 (20) | 0.4 |
DLcCOVA % of predicted, mean (±SD) 2 | 74 (23) | 77 (22) | 0.3 |
Baseline spirometry 2 | |||
FEV1% of predicted | 52.5 (21.1) | 58.4 (18.0) | <0.0001 |
FVC% of predicted | 68.1 (19.0) | 76.2 (17.6) | <0.0001 |
FEV1/FVC of predicted, mean (±SD) | 61.6 (15.7) | 61.5 (13.4) | 0.7 |
Spirometry after bronchodilatation 2 | |||
FEV1% of predicted | 57.7 (20.3) | 61.7 (16.8) | 0.04 |
FVC% of predicted | 71.5 (17.9) | 79.1 (16.9) | <0.0001 |
FEV1/FVC of predicted, mean (±SD) | 64.3 (14.8) | 62.9 (13.2) | 0.2 |
Proportion (%) of patients at GOLD 1 | |||
former stage 0: FEV1≥80% | 11.2 | 9.5 | |
stage 1: FEV1/FVC<70%, FEV1≥80% | 1.0 | 3.0 | |
stage 2: FEV1/FVC<70%, 50%≤FEV1<80% | 24.5 | 40.4 | |
stage 3: FEV1/FVC<70%, 30%≤FEV1<50% | 18.4 | 18.0 | |
stage 4: FEV1/FVC<70%, FEV1<30% | 9.2 | 4.3 | |
stage undefined: FEV1/FVC≥70%, FEV1<80% | 35.7 | 24.8 | 0.02 |
Proportion (%) of patients with home oxygen therapy | 8.6 | 1.7 | <0.0001 |
In severe COPD (FEV1<50% of predicted) 2 | |||
Arterial O2 pressure, mean (±SD) | 9.0 (1.5) | 9.7 (14) | 0.006 |
Arterial CO2 pressure, mean (±SD) | 5.5 (0.9) | 5.3 (0.5) | 0.4 |
Proportion (%) of deaths during follow-up1 | 9.9 | 5.5 | 0.05 |
HRQL scores, mean (±SD) 2 | |||
Airway-specific (range 20–0) | 13.0 (3.6) | 6.9 (4.5) | <0.0001 |
Generic (range 0–1) | 0.63 (0.06) | 0.83 (0.07) | <0.0001 |
Proportion (%) of patients 1 | |||
Underweight BMI < 20 | 1.4 | 3.1 | |
Normal weight BMI 20–25 | 33.6 | 41.2 | |
Overweight BMI 25–30 | 53.6 | 50.1 | |
Obese BMI > 30 | 11.4 | 5.6 | 0.04 |
Proportion (%) of patients with co-commitant 1 | |||
Coronary disease | 27.0 | 20.2 | 0.07 |
Cerebrovascular disease | 12.5 | 6.2 | 0.009 |
Cardiovascular disease | 37.5 | 25.6 | 0.004 |
Diabetes | 25.7 | 12.4 | <0.0001 |
Peripheral artery occlusive disease | 3.9 | 4.7 | 0.7 |
Metabolic syndrome | 32.9 | 19.0 | 0.001 |
Alcohol abuse | 21.7 | 13.3 | 0.01 |
Psychiatric condition | 17.8 | 8.3 | 0.001 |
Hypertension | 46.7 | 39.0 | 0.09 |