Figure 4

Variation of total phenytoin, adjusted phenytoin, and free phenytoin with respect to patient age. (A) Variation of the difference between PHT_total/10 and PHT_free with respect to patient age. All data from chronologically first phenytoin measurements in 756 patients. The dashed line is from linear regression: [PHT_total/10 - PHT_free] = -0.394 + 0.0038*(patient age) (R² = 0.01). The 95% confidence intervals of the intercept is (-0.464, -0.372) and for the slope is (-0.056, 0.064). (B) Variation of the difference between PHT_free and PHT_{adj_free} with respect to patient age is shown using same source of data as in (A). The dashed line is from linear regression: [PHT_free - PHT_{adj_free}] = 0.0838 + 0.0021 * age (R² = 0.004). The 95% confidence intervals of the intercept is (-0.0072, 0.174) and for the slope is (-0.053, 0.057)