Table 3 Annotation guide for articles that were deemed to potentially motivate a review update on their topic
Annotation | Description |
|---|---|
A | Study includes evidence on new or serious adverse events relevant to this topic. |
P | Study includes new patient subgroup, new indication, or evidence specific to new comorbidity. |
B | Study is notably better designed, or uses novel methods, compared to prior studies. |
L | Study uses a significantly larger sample size than prior studies for this topic. |
M | Study includes other significant evidence that may motivate a review update, when taken in combination with other studies. |