Table 1 Biomarker retrieval terminology classes and coverage of the terminology in the annotated corpora
Terminology class | Description | Examples | Annotation found in abstracts |
|---|---|---|---|
Clinical Management | Terms indicating clinical investigations on patients | Patient; Cohort study | 96% |
Diagnostics | Terms representing clinical as well as molecular diagnostics | Immunohistochemistry; Emission Tomography; Microarray | 85% |
Prognosis | Terms indicating the prediction for a patient /kind of biomarker/ outcome of therapies | Surrogate end point; clinical response; biomarker; predictor | 88% |
Statistics | Statistical methods indicating the strength of the biomarker relationship | Chi(2) test; mean +/− SD; univariate analysis; Kaplan-Meier Analysis | 48% |
Evidence | Terms describing genetic/ molecular evidence for activity of a gene | Mutation; gene amplification; polymorphism; expression | 82% |
Antecedent | Terms expressing exposure to hazardous agents and risk factors | Smoker; susceptibility; exposure | 20% |