|
calendar year
|
2004 (2003-2006)
|
2006 (2004-2007)
|
2004 (2002-2005)
|
|
HIV-1 RNA log10 copies/ml
|
4.53 (3.83-5.12)
|
5.08 (4.63-5.5)
|
4.18 (3.63-4.8)
|
|
CD4+ count cells/mm3
|
273 (147-389)
|
191 (70-300)
|
296.8 (192-435)
|
|
Age years
|
40 (36-45)
|
39 (33-45)
|
40 (37-45)
|
|
GSS
|
Rega
|
3 (2-3)
|
3 (3-3)
|
2 (1.5-3)
|
| |
ANRS
|
3 (2-3)
|
3 (3-3)
|
2 (1.5-3)
|
| |
HIVdb
|
3 (2-3)
|
3 (3-3)
|
2 (1.5-3)
|
|
Categorical variables
|
n (%)
|
n (%)
|
n (%)
|
|
#patients
|
2158
|
733 (34.0%)
|
1425 (57.7%)
|
|
#cART regimens
|
2337
|
733 (31.4%)
|
1604 (68.6%)
|
|
cART type
|
2NRTI+1NNRTI
|
516 (23.9%)
|
235 (32.1%)
|
281 (19.7%)
|
| |
2NRTI+1PI
|
243 (11.3%)
|
45 (6.1%)
|
198 (13.9%)
|
| |
2NRTI+1PI/r
|
1306 (60.5%)
|
441 (60.2%)
|
865 (60.7%)
|
| |
3NRTI
|
93 (4.3%)
|
12 (1.6%)
|
81 (5.7%)
|
|
gender
|
male
|
1546 (71.6%)
|
563 (76.8%)
|
983 (69%)
|
|
previous AIDS-defining events (yes vs. no)
|
285 (13.2%)
|
92 (12.6%)
|
193 (13.5%)
|
|
Nationality
|
Italian
|
1524 (70.6%)
|
529 (72.2%)
|
995 (69.8%)
|
| |
non-Italian
|
168 (7.8%)
|
98 (13.4%)
|
70 (4.9%)
|
| |
unknown
|
466 (21.6%)
|
106 (14.5%)
|
360 (25.3%)
|
|
mode of HIV-1 transmission
|
heterosexual
|
657 (30.4%)
|
262 (35.7%)
|
395 (27.7%)
|
| |
male homosexual
|
362 (16.8%)
|
154 (21%)
|
208 (14.6%)
|
| |
IDU
|
468 (21.7%)
|
54 (7.4%)
|
414 (29.1%)
|
| |
other/unknown
|
671 (31.1%)
|
263 (35.9%)
|
408 (28.6%)
|
|
HBV/HCV co-infection
|
positive
|
605 (28%)
|
149 (20.3%)
|
456 (32%)
|
| |
negative
|
483 (22.4%)
|
260 (35.5%)
|
223 (15.6%)
|
| |
unknown
|
1070 (49.6%)
|
324 (44.2%)
|
746 (52.4%)
|
|
interval time from the first HIV-1 positive test to cART initiation
|
< = 12 months
|
444 (20.6%)
|
354 (48.3%)
|
90 (6.3%)
|
| |
> 12 and < = 60 months
|
188 (8.7%)
|
45 (6.1%)
|
143 (10%)
|
| |
> 60 months
|
575 (26.6%)
|
61 (8.3%)
|
514 (36.1%)
|
| |
unknown
|
951 (44.1%)
|
273 (37.2%)
|
678 (47.6%)
|
|
duration of prior ART exposures
|
< = 6 months
|
1197 (55.5%)
|
733 (100%)
|
464 (32.6%)
|
| |
> 6 and < = 12 months
|
117 (5.4%)
|
N/A
|
117 (8.2%)
|
| |
> 12 and < = 24 months
|
184 (8.5%)
|
N/A
|
184 (12.9%)
|
| |
> 24 months
|
660 (30.6%)
|
N/A
|
660 (46.3%)
|
|
viral subtype
|
B
|
1753 (81.2%)
|
503 (68.6%)
|
1250 (87.7%)
|
| |
02_AG
|
56 (2.6%)
|
28 (3.8%)
|
28 (2%)
|
| |
C
|
41 (1.9%)
|
31 (4.2%)
|
10 (0.7%)
|
| |
F1
|
54 (2.5%)
|
39 (5.3%)
|
15 (1.1%)
|
| |
other
|
60 (2.8%)
|
35 (4.8%)
|
25 (1.8%)
|
| |
undetermined
|
194 (9%)
|
97 (13.2%)
|
97 (6.8%)
|
|
#previous ART switches
|
none
|
733 (34%)
|
733 (100%)
|
N/A
|
| |
one/two
|
429 (19.9%)
|
N/A
|
429 (30.1%)
|
| |
three to six
|
605 (28%)
|
N/A
|
605 (42.5%)
|
| |
more than six
|
391 (18.1%)
|
N/A
|
391 (27.4%)
|
|
previous exposure to suboptimal ART (yes vs. no)
|
922 (42.7%)
|
N/A
|
922 (64.7%)
|
|
previous ART class exposure
|
none
|
733 (34%)
|
733 (100%)
|
N/A
|
| |
only NRTI
|
94 (4.4%)
|
N/A
|
94 (6.6%)
|
| |
NRTI and NNRTI
|
220 (10.2%)
|
N/A
|
220 (15.4%)
|
| |
NRTI, NNRTI and PI
|
252 (11.7%)
|
N/A
|
252 (17.7%)
|
| |
NRTI, NNRTI and PI/r
|
466 (21.6%)
|
N/A
|
466 (32.7%)
|
| |
NRTI and PI
|
229 (10.6%)
|
N/A
|
229 (16.1%)
|
| |
NRTI and PI/r
|
134 (6.2%)
|
N/A
|
134 (9.4%)
|
| |
other classes
|
30 (1.4%)
|
N/A
|
30 (2.1%)
|
