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Table 3 Regression equation variables for prediction of the growth response to GH therapy during various treatment periods in short children born SGA

From: Prediction models for short children born small for gestational age (SGA) covering the total growth phase. Analyses based on data from KIGS (Pfizer International Growth Database)

 

Prepubertal years

Total pubertal growth

 

1st year

2nd year

3rd year

4th year (@)

 

male (@)

female (@)

Parameter

        

Parameter

    

N

613

 

385

 

317

 

180

  

355

 

221

 

R2

0.52

 

0.34

 

0.33

 

0.30

  

0.66

 

0.65

 

Error SD (cm)

1.3

 

1.1

 

1.0

 

1.0

  

4.5

 

3.8

 

Parameter estimate (PE)

PE

Rank

PE

Rank

PE

Rank

PE

Rank

 

PE

Rank

PE

Rank

Intercept (constant)

9.4

 

4.7

 

6.2

 

6.0

 

Intercept

72.6

 

57.0

 

Age at start

(years)

-0.31

2

-0.11

2

-0.18

2

-0.05

4

Age puberty onset (years)

-4.0

1

-3.7

1

Weight at start

(SDS)

0.30

3

-

-

0.19

3

0.40

1

Age - Bone age (years)

1.4

2

1.7

2

GH dose at year start

(mg/kg/day)

56.51

1

13.46

3

1.21#

5

0.87&

3

Mean GH dose

(mg/kg/week)

8.8

4

9.5

4

MPH (SDS)

0.11 *

4

-

-

0.12$

4

-

-

Height - MPH $

(SDS)

-1.3

3

-1.2

3

HV in previous year (cm/year)

-

-

0.30

1

0.26

1

0.21

2

_

_

_

_

_

  1. * = based on Tanner references; $ [8] = based on Prader references [9]; # = mg/kg/week; &= ln IU/kg/week; @ = based on GHD model (Ranke et al., 1999) [17]