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Table 3 Regression equation variables for prediction of the growth response to GH therapy during various treatment periods in short children born SGA

From: Prediction models for short children born small for gestational age (SGA) covering the total growth phase. Analyses based on data from KIGS (Pfizer International Growth Database)

  Prepubertal years Total pubertal growth
  1st year 2nd year 3rd year 4th year (@)   male (@) female (@)
Parameter          Parameter     
N 613   385   317   180    355   221  
R2 0.52   0.34   0.33   0.30    0.66   0.65  
Error SD (cm) 1.3   1.1   1.0   1.0    4.5   3.8  
Parameter estimate (PE) PE Rank PE Rank PE Rank PE Rank   PE Rank PE Rank
Intercept (constant) 9.4   4.7   6.2   6.0   Intercept 72.6   57.0  
Age at start
(years)
-0.31 2 -0.11 2 -0.18 2 -0.05 4 Age puberty onset (years) -4.0 1 -3.7 1
Weight at start
(SDS)
0.30 3 - - 0.19 3 0.40 1 Age - Bone age (years) 1.4 2 1.7 2
GH dose at year start
(mg/kg/day)
56.51 1 13.46 3 1.21# 5 0.87& 3 Mean GH dose
(mg/kg/week)
8.8 4 9.5 4
MPH (SDS) 0.11 * 4 - - 0.12$ 4 - - Height - MPH $
(SDS)
-1.3 3 -1.2 3
HV in previous year (cm/year) - - 0.30 1 0.26 1 0.21 2 _ _ _ _ _
  1. * = based on Tanner references; $ [8] = based on Prader references [9]; # = mg/kg/week; &= ln IU/kg/week; @ = based on GHD model (Ranke et al., 1999) [17]