Prediction models for short children born small for gestational age (SGA) covering the total growth phase. Analyses based on data from KIGS (Pfizer International Growth Database)

Table 2 Characteristics of the SGA patients used for the present analysis

	1^st pre-pubertal year			2^nd pre-pubertal year			3^rd pre-pubertal year			4^th pre-pubertal year
	N	Mean	SD	N	Mean	SD	N	Mean	SD	N	Mean	SD
At GH treatment start
Sex male %	2340	62		1358	65		317	72		182	62
Birth weight SDS	2339	-2.6	1.0	1357	-2.6	1.0	316	-2.6	1.0	181	-2.8	1.0
Birth length SDS	1927	-2.5	1.3	1132	-2.6	1.3	254	-2.8	1.4	155	-3.1	1.4
Maximum GH peak (ng/ml)	1324	19.5	13.6	804	20.2	14.6	221	19.2	14.4	116	21.2	15.4
MPH SDS	2157	-1.2	1.2	1253	-1.1	1.2	317	-0.9	1.3	167	-0.7	1.3
Age (years)	2340	7.2	3.1	1358	6.7	2.8	315	5.5	2.1	182	3.7	0.9
Height SDS	2340	-3.4	1.0	1358	-3.5	1.0	317	-3.7	1.1	182	-4.2	1.3
Weight SDS	2340	-3.1	1.5	1358	-3.2	1.5	317	-3.6	1.7	182	-4.2	1.9
HV(cm/year)	756	5.4	1.9	486	5.5	1.9	140	5.6	3.7	88	6.5	2.1
GH dose (mg/kg/week)	2340	0.30	0.10	1358	0.31	0.11	317	0.30	0.11	182	0.31	0.11
First-year growth response
HV (cm/year)	2340	8.5	2.1	1358	8.7	2.0	310	9.0	2.0	173	9.5	2.0
Change in (delta) height SDS	2340	0.75	0.44	1358	0.79	0.43	310	0.82	0.43	173	1.0	0.5
Second year growth response
HV(cm/year)				1358	7.2	1.5	317	7.4	1.4	174	7.9	1.5
Change in (delta) height SDS				1358	0.45	0.28	310	0.47	0.27	174	0.6	0.3
Third year growth response
HV(cm/year)							317	6.6	1.2	182	6.9	1.4
Change in (delta) height SDS							317	0.32	0.22	182	0.31	0.29
Fourth year growth response
HV(cm/year)										182	6.1	1.2
Change in (delta) height SDS										182	0.20	0.25
Observed vs. predicted	1 ^st yr			2 ^nd yr			3 ^rd yr			4 ^th yr
Predicted HV(cm/yr)	1895	8.84	1.13	1104	7.08	0.67	317	6.60	0.71	171	6.19	0.78
Observed HV (cm/yr)	1895	8.48	1.90	1104	7.13	1.45	317	6.60	1.24	171	6.10	1.17
Student. Residual (SDS)	1895	-0.27	1.29	1104	0.04	1.22	317	0.00	1.01	171	-0.10	1.19

1st, 2nd, 3rd and 4th prepubertal years and the comparison between observed and predicted height velocities within respective years are shown.
Calculated derivates of height data (SDS, MPH) are based on Prader's references. [9]

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