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Table 2 Characteristics of the SGA patients used for the present analysis

From: Prediction models for short children born small for gestational age (SGA) covering the total growth phase. Analyses based on data from KIGS (Pfizer International Growth Database)

  1st pre-pubertal year 2nd pre-pubertal year 3rd pre-pubertal year 4th pre-pubertal year
  N Mean SD N Mean SD N Mean SD N Mean SD
At GH treatment start             
   Sex male % 2340 62   1358 65   317 72   182 62  
   Birth weight SDS 2339 -2.6 1.0 1357 -2.6 1.0 316 -2.6 1.0 181 -2.8 1.0
   Birth length SDS 1927 -2.5 1.3 1132 -2.6 1.3 254 -2.8 1.4 155 -3.1 1.4
   Maximum GH peak (ng/ml) 1324 19.5 13.6 804 20.2 14.6 221 19.2 14.4 116 21.2 15.4
   MPH SDS 2157 -1.2 1.2 1253 -1.1 1.2 317 -0.9 1.3 167 -0.7 1.3
   Age (years) 2340 7.2 3.1 1358 6.7 2.8 315 5.5 2.1 182 3.7 0.9
   Height SDS 2340 -3.4 1.0 1358 -3.5 1.0 317 -3.7 1.1 182 -4.2 1.3
   Weight SDS 2340 -3.1 1.5 1358 -3.2 1.5 317 -3.6 1.7 182 -4.2 1.9
   HV(cm/year) 756 5.4 1.9 486 5.5 1.9 140 5.6 3.7 88 6.5 2.1
   GH dose (mg/kg/week) 2340 0.30 0.10 1358 0.31 0.11 317 0.30 0.11 182 0.31 0.11
First-year growth response             
   HV (cm/year) 2340 8.5 2.1 1358 8.7 2.0 310 9.0 2.0 173 9.5 2.0
   Change in (delta) height SDS 2340 0.75 0.44 1358 0.79 0.43 310 0.82 0.43 173 1.0 0.5
Second year growth response             
   HV(cm/year)     1358 7.2 1.5 317 7.4 1.4 174 7.9 1.5
   Change in (delta) height SDS     1358 0.45 0.28 310 0.47 0.27 174 0.6 0.3
Third year growth response             
   HV(cm/year)        317 6.6 1.2 182 6.9 1.4
   Change in (delta) height SDS        317 0.32 0.22 182 0.31 0.29
Fourth year growth response             
   HV(cm/year)           182 6.1 1.2
   Change in (delta) height SDS           182 0.20 0.25
Observed vs. predicted 1 st yr    2 nd yr    3 rd yr    4 th yr   
   Predicted HV(cm/yr) 1895 8.84 1.13 1104 7.08 0.67 317 6.60 0.71 171 6.19 0.78
   Observed HV (cm/yr) 1895 8.48 1.90 1104 7.13 1.45 317 6.60 1.24 171 6.10 1.17
   Student. Residual (SDS) 1895 -0.27 1.29 1104 0.04 1.22 317 0.00 1.01 171 -0.10 1.19
  1. 1st, 2nd, 3rd and 4th prepubertal years and the comparison between observed and predicted height velocities within respective years are shown.
  2. Calculated derivates of height data (SDS, MPH) are based on Prader's references. [9]