GenDrux: A biomedical literature search system to identify gene expression-based drug sensitivity in breast cancer

Table 1 Disease-Gene Expression-Drug Sensitivity Relationships in Breast Cancer

	Disease	Gene	Drug	Sensitivity*	Ref.
1	Breast cancer	estrogen-induced genes	Estrogen	increase	[8]
2	Breast cancer	Her-2/ErbB2	Tamoxifen	decrease	[9]
3	NSCLC, gastric	ERCC1, BRCA1	Cisplatin, docetaxel	Decrease
4	Breast cancer	estrogen receptor, progesterone receptor, HER2, Ki-67, p53, and bcl-2	Doxorubicin, docetaxel, tamoxifen	decrease (estrogen R, Kip67), increase (Bcl2)	[10, 11]
5	Breast cancer	Glutathione peroxidase	DHA, doxorubicin	increase	[12]
6	Breast cancer	Aromatase Inhibitor, pS2	Letrozole	increase	[13]

Decrease suggests that increased expression of the mentioned gene decreases the drug sensitivity, or makes the drug more resistant.

ISSN: 1472-6947