Table 1 National Comprehensive Cancer Network (NCCN) risk grouping for prostate cancer [7]
From: A personalized decision aid for prostate cancer shared decision making
Risk category for DA | NCCN risk group | Clinical and pathologic features |
|---|---|---|
Low | Very low | All of the following features |
cT1c | ||
Grade Group 1 | ||
PSA < 10 ng/mL | ||
< 3 positive biopsy cores, < 50% in each core | ||
Low | All of the following but doesn’t qualify for very low risk | |
cT1c-T2a | ||
Grade Group 1 | ||
PSA < 10 ng/mL | ||
Intermediate | Favorable intermediate | All of the following features |
1 intermediate risk factor (cT2b-T2c, Grade Group 2, PSA 10-20Â ng/mL) | ||
Grade Group 1 or 2 | ||
< 50% biopsy cores positive | ||
Unfavorable intermediate | One or more of the following | |
2 or 3 intermediate risk factors (cT2b-T2c, Grade Group 2 or 3, PSA 10-20Â ng/mL) | ||
Grade Group 3 | ||
≥ 50% biopsy cores positive | ||
High | High | No very high risk features and exactly one high risk feature |
cT3a | ||
Grade Group 4 or 5 | ||
PSA > 20 ng/mL | ||
Very High | At least one of the following | |
cT3b-T4 | ||
Primary Gleason pattern 5 | ||
2 or 3 high risk features | ||
> 4 cores with Grade Group 4 or 5 |