Applying openEHR’s Guideline Definition Language to the SITS international stroke treatment registry: a European retrospective observational study

Table 1 Results of non-compliance obtained by openEHR’s Guideline Definition Language (GDL) and compared to conventional analysis

Contraindication to Thrombolysis Treatment	Non-Compliance (%)
	2006–2007		2010–2011
	CA	GDL	CA	GDL
NIHSS score > 25	1.1	1.1	1.7	1.7
Anticoagulation treatment	2.4	2.4	3.1	3.1
Systolic blood pressure > 185 mmHg	2.5	2.5	5.4	5.4
Systolic blood pressure > 184 mmHg	4.0	4.0	6.3	6.3
Diastolic blood pressure > 110 mmHg	0.8	0.8	2.1	2.1
Diastolic blood pressure > 109 mmHg	2.1	2.1	3.6	3.6
Diabetes and previous stroke	2.5	2.5	2.8	2.8
Blood glucose < 50 mg/dl or > 400 mg/dl	0.3	0.3	0.3	0.3
Age > 80 years	8.9	8.9	17.2	17.2
Stroke onset > 3 h ago	8.2	8.2	27.9	27.9
Stroke onset > 4.5 h ago	0.9	0.9	1.8	1.8

The guidelines and regulations from the European Stroke Organisation [23, 24] and European Medicines Agency [25] respectively are in the form of contraindications to the use of a decisive stroke treatment – intravenous thrombolysis. These results from GDL and archetypes completely match results from conventional statistical software where the clinical question was studied in detail [11]
CA conventional analysis, NIHSS National Institutes of Health Stroke Scale

ISSN: 1472-6947