Figure 2

Example of thea prioridose estimation function. This shows an example of an a priori dose estimation for a 5 year old child, with bodyweight 20 kg, genotypes CYP2C9 *2/*2 and VKORC1 A/A, with a target INR of 2.0-3.0 and a baseline INR of 1.2. The estimated maintenance dose is 0.7 mg/24h, or 4.9 mg/week. The graph indicate that with this dose regimen, time to reach a target INR is ~6 days, and time to steady state is ~12 days.