Biomarker/exposure characteristicsa | Ratio of population benefit (RPB) | Net benefit (NB) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
(Threshold)b | OR | PAR% | Sen. | Spe. | RPB | RPB | RPB | NB | NB | NB |
(EA, f 0.03) | (Breast ca, f 0.06) | (Ovarian ca, f=0.15) | (EA, f=0.03) | (Breast ca, f=0.06) | (Ovarian ca, f=0.15) | |||||
Fixed sensitivity (95%) | 1.5 | 33.22 | 0.95 | 0.07 | -0.456 | -0.659 | -0.812 | -0.018 | -0.046 | -0.129 |
2 | 48.88 | 0.95 | 0.09 | -0.440 | -0.641 | -0.792 | -0.017 | -0.045 | -0.126 | |
4 | 71.30 | 0.95 | 0.16 | -0.389 | -0.583 | -0.728 | -0.015 | -0.040 | -0.115 | |
10 | 84.46 | 0.95 | 0.29 | -0.287 | -0.466 | -0.601 | -0.011 | -0.032 | -0.095 | |
20 | 89.01 | 0.95 | 0.43 | -0.187 | -0.352 | -0.475 | -0.007 | -0.024 | -0.075 | |
50 | 92.25 | 0.95 | 0.61 | -0.051 | -0.196 | -0.305 | -0.002 | -0.014 | -0.048 | |
Fixed specificity (95%) | 1.5 | 2.59 | 0.08 | 0.95 | -0.019 | -0.032 | -0.043 | -0.001 | -0.002 | -0.007 |
2 | 4.95 | 0.10 | 0.95 | -0.013 | -0.029 | -0.041 | -0.001 | -0.002 | -0.007 | |
4 | 12.67 | 0.17 | 0.95 | 0.006 | -0.018 | -0.036 | 0.000 | -0.001 | -0.006 | |
10 | 27.40 | 0.31 | 0.95 | 0.041 | 0.002 | -0.028 | 0.002 | 0.000 | -0.004 | |
20 | 41.15 | 0.44 | 0.95 | 0.074 | 0.021 | -0.019 | 0.003 | 0.001 | -0.003 | |
50 | 60.16 | 0.62 | 0.95 | 0.119 | 0.047 | -0.008 | 0.005 | 0.003 | -0.001 | |
Balanced sensitivity & specificityc | 1.5 | 14.83 | 0.54 | 0.54 | -0.208 | -0.316 | -0.397 | -0.008 | -0.022 | -0.063 |
2 | 23.89 | 0.57 | 0.57 | -0.178 | -0.285 | -0.366 | -0.007 | -0.020 | -0.058 | |
4 | 42.57 | 0.64 | 0.63 | -0.114 | -0.222 | -0.304 | -0.005 | -0.015 | -0.048 | |
10 | 60.28 | 0.72 | 0.72 | -0.030 | -0.137 | -0.218 | -0.001 | -0.010 | -0.035 | |
20 | 70.68 | 0.78 | 0.77 | 0.024 | -0.085 | -0.166 | 0.001 | -0.006 | -0.026 | |
50 | 80.17 | 0.84 | 0.84 | 0.088 | -0.020 | -0.101 | 0.003 | -0.001 | -0.016 |