Biomarker/exposure characteristics | Ratio of population benefit (RPB) | Net benefit (NB) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
OR | Prevalence (%) | PAR% | Sen. | Spe. | RPB | RPB | RPB | NB | NB | NB |
(EA, f 0.03) | (Breast ca, f 0.06) | (Ovarian ca, f 0.15) | (EA, f 0.03) | (Breast ca, f 0.06) | (Ovarian ca, f 0.15) | |||||
1.5 | 0.1 | 0.05 | 0.001 | 0.999 | -0.000 | -0.001 | -0.001 | -0.000 | -0.000 | -0.000 |
2 | 0.1 | 0.10 | 0.002 | 0.999 | -0.000 | -0.001 | -0.001 | -0.000 | -0.000 | -0.000 |
4 | 0.1 | 0.29 | 0.004 | 0.999 | 0.000 | -0.000 | -0.001 | 0.000 | -0.000 | -0.000 |
10 | 0.1 | 0.81 | 0.009 | 0.999 | 0.002 | 0.001 | -0.000 | 0.000 | 0.000 | -0.000 |
20 | 0.1 | 1.56 | 0.017 | 0.999 | 0.004 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
50 | 0.1 | 3.19 | 0.033 | 0.999 | 0.008 | 0.004 | 0.001 | 0.000 | 0.000 | 0.000 |
1.5 | 1 | 0.49 | 0.015 | 0.990 | -0.004 | -0.006 | -0.008 | -0.000 | -0.000 | -0.001 |
2 | 1 | 0.97 | 0.020 | 0.990 | -0.002 | -0.006 | -0.008 | 0.000 | -0.000 | -0.001 |
4 | 1 | 2.81 | 0.038 | 0.990 | 0.002 | -0.003 | -0.007 | 0.000 | -0.000 | -0.001 |
10 | 1 | 7.61 | 0.085 | 0.991 | 0.015 | 0.004 | -0.003 | 0.001 | 0.000 | -0.001 |
20 | 1 | 13.93 | 0.148 | 0.991 | 0.031 | 0.014 | 0.001 | 0.001 | 0.001 | 0.000 |
50 | 1 | 26.33 | 0.271 | 0.993 | 0.063 | 0.033 | 0.010 | 0.002 | 0.002 | 0.002 |
1.5 | 10 | 4.70 | 0.142 | 0.900 | -0.039 | -0.065 | -0.084 | -0.002 | -0.004 | -0.013 |
2 | 10 | 8.94 | 0.180 | 0.901 | -0.029 | -0.059 | -0.082 | -0.001 | -0.004 | -0.013 |
4 | 10 | 22.54 | 0.303 | 0.902 | 0.003 | -0.040 | -0.073 | 0.000 | -0.003 | -0.012 |
10 | 10 | 46.05 | 0.514 | 0.904 | 0.058 | -0.008 | -0.057 | 0.002 | -0.001 | -0.009 |
20 | 10 | 63.92 | 0.675 | 0.906 | 0.100 | 0.017 | -0.046 | 0.004 | 0.001 | -0.007 |
50 | 10 | 81.79 | 0.836 | 0.907 | 0.141 | 0.041 | -0.034 | 0.006 | 0.003 | -0.005 |
1.5 | 30 | 12.90 | 0.390 | 0.701 | -0.125 | -0.200 | -0.256 | -0.005 | -0.014 | -0.041 |
2 | 30 | 22.80 | 0.460 | 0.702 | -0.107 | -0.189 | -0.251 | -0.004 | -0.013 | -0.040 |
4 | 30 | 46.84 | 0.628 | 0.703 | -0.064 | -0.163 | -0.238 | -0.003 | -0.011 | -0.038 |
10 | 30 | 72.43 | 0.807 | 0.705 | -0.017 | -0.136 | -0.225 | -0.001 | -0.009 | -0.036 |
20 | 30 | 84.69 | 0.893 | 0.706 | 0.005 | -0.123 | -0.219 | 0.000 | -0.009 | -0.035 |
50 | 30 | 93.44 | 0.954 | 0.707 | 0.021 | -0.114 | -0.215 | 0.001 | -0.008 | -0.034 |
1.5 | 70 | 25.71 | 0.777 | 0.301 | -0.327 | -0.486 | -0.606 | -0.013 | -0.034 | -0.096 |
2 | 70 | 40.89 | 0.823 | 0.301 | -0.316 | -0.480 | -0.603 | -0.013 | -0.033 | -0.096 |
4 | 70 | 67.46 | 0.902 | 0.302 | -0.295 | -0.467 | -0.597 | -0.012 | -0.032 | -0.095 |
10 | 70 | 86.14 | 0.958 | 0.303 | -0.280 | -0.459 | -0.593 | -0.011 | -0.032 | -0.094 |
20 | 70 | 92.92 | 0.979 | 0.303 | -0.275 | -0.456 | -0.591 | -0.011 | -0.032 | -0.094 |
50 | 70 | 97.13 | 0.991 | 0.303 | -0.272 | -0.454 | -0.591 | -0.011 | -0.031 | -0.094 |