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Table 1 Literature analysis result.

From: Generation and application of drug indication inference models using typed network motif comparison analysis

Rank

Chemical Name

CasRN

Literature Title

1

Cyclosporine

59865-13-3

The concentration of cyclosporine metabolites is significantly lower in kidney transplant recipients with diabetes mellitus. [17]

2

Heparin

9005-49-6

Diabetes Mellitus, Glycoprotein IIb/IIIa Blockade, and Heparin. [18]

3

Cholecalciferol

67-97-0

Effect of cholecalciferol supplementation on blood glucose in an experimental model of type 2 diabetes mellitus in spontaneously hypertensive rats and Wistar rats. [19]

4

Azacitidine

320-67-2

Newly inferred indication.

5

Cysteine

52-90-4

Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. [20]

6

Chenodeoxycholic Acid

474-25-9

In the search for specific inhibitors of human 11beta-hydroxysteroid-dehydrogenases (11beta-HSDs): chenodeoxycholic acid selectively inhibits 11beta-HSD-I. [21]

7

Diethylstilbestrol

56-53-1

The effect of diethylstilbestrol upon alloxan diabetes in the male rat. [22]

8

Tretinoin

302-79-4

Newly inferred indication.

9

Daunorubicin

20830-81-3

Newly inferred indication.

10

Ursodeoxycholic Acid

128-13-2

Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes. [23]

  1. Related literatures for the top 10 highest scored indications of 'T2DM' from enhanced4-node TNMCA model. Cycloporine [17], Heparin [18], Cholecalciferol [19], Cycteine [20], Chenodeoxycholic Acid [21], Diethylstilbestrol [22], and Ursodeoxycholic Acid [23] were reported to have interactions with 'T2DM'.