Type 2 diabetes genetic association database manually curated for the study design and odds ratio

Table 1 Comparison of T2D related DB with T2DGADB

	T2DGADB	T2D-DB¹	Hindorff et al.²	Johnson et al.³	T1Dbase⁴
T2D Candidate genes	530	330	50	476
Unique genes	421	NS	23	380
T2D Candidate SNP Markers	2108	NS	76	6076
Unique Markers	1874	NS	28	5841
T2DM publication	701	8963	23	12
coverage year	2000 ~ 2009. 10	~ 2009. 1	2005 ~ 2010. 10	2002. 12 ~ 2008. 2	~ 2010. 10
data coverage	T2D candidate gene approach, GWAS	T2D candidate gene approach, GWAS	GWAS (disease/trait)	GWAS (disease/trait)	T1D candidate gene approach, GWAS
association data format	text, graph	NA	text	text	text
feature	summary of T2D related genetic association study results(sample size, gene, SNP, MAF, p-value, OR, covariant, etc.)	summary of molecular factors using public databases (EST, Transcripts, Unigene, Homologene, GO, Pathways, Tissue Specific Expression, Protein-Protein interactor, Riskfactors, Complications)	summary of GWAS data (Disease, sample size, gene, SNP, MAF, p-value, OR, platform, CNV, etc.)	summary of GWAS data (Disease, sample size, gene, SNP, MAF, p-value, OR, platform, CNV, etc.)	summary of T1D related molecular factors (T1D susceptibility regions, Genetic data, Microarray data, functional annotation, Network & Pathway), analysis tools

1. T2D-Db: an integrated platform to study the molecular basis of Type 2 diabetes. Agrawal S et al. BMC Genomics. 2008 Jul 7;9:320.
2. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Hindorff LA et al. Proc Natl Acad Sci USA. 2009 Jun 9;106(23):9362-7.
3. An open access database of genome-wide association results. Johnson AD et al. BMC Med Genet. 2009 Jan 22;10:6.
4. T1DBase: integration and presentation of complex data for type 1 diabetes research. Hulbert EM et al. Nucleic Acids Res. 2007 Jan;35(Database issue):D742-6.

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